Biotechnology Journal
Biotechnol. J. 2014, 9, 711–712
DOI 10.1002/biot.201400304
www.biotechnology-journal.com
Editorial: Industrial biotechnology – Technologies and methods for rapid process development
T
he world is faced with significant challenges in securing the supply of energy, transportation fuels, food as well as high and low value chemicals. At the same time, people are aiming to improve their living standard regarding nutrition and health. Industrial biotechnology plays a key role in finding solutions for these challenges. At the 2nd European Conference on Applied Biotechnology (ECAB2) in The Hague, The Netherlands, April 2013, it was clear that industrial biotechnology is a growing area. The ECAB2 was held successfully in conjunction with the 9th European Conference on Chemical Engineering (ECCE9) and attracted ~1900 attendees from academia and industry around the world. Many key areas of contemporary industrial biotechnology were highlighted at the conference: biomedical engineering (e.g. cell and tissue engineering), classical biotechnology (e.g. biocatalysis, systems biotechnology, metabolic engineering, the cell factory, proteomics and biotransformation), bioreactor engineering (bioreactors, fermentation technology, fermentation control), analytical technologies (e.g. PAT, bio-sensors, high-throughput screening), separation and downstream processing (e.g. affinity separations, chromatography, membrane technology), renewable energy and feedstock (e.g. bioenergy, biorefineries, renewables, biofuels, algae, marine biotechnology, bio-based products, biomass process technology). The ECAB is a biannual conference organized by the European Society of Biochemical Engineering Science, the ESBES, whose foundation was celebrated at the ECAB2 [1].
This Special Issue (SI) compiles a selection of invited key contributions, original research papers as well as a selection of reviews and perspectives, describing innovative approaches in industrial biotechnology. Two articles by Krist Gernaey et al. [2] and Jarka Glassey et al. [3] offer perspectives on the state-ofthe-art in hybrid modelling in biopharmaceutical manufacturing and in industrial fermentation technology, respectively. They highlight the specific challenges researchers in industry and academia are facing and offer recommendations on research and technology transfer. Contributions by Ioanna Hariskos and Clemens Posten [4] and Adisa Azapagic et al. [5] focus on important areas of biorefinery, reviewing opportunities and constraints for biorefining various products from microalgae, discussing the factors influencing the potential success of such processes and assessing the environmental sustainability of ethanol from biorefineries, respectively. Industrial biotechnology plays a key role in finding solutions for current worldwide challenges. Biopharmaceutical manufacturing is a rapidly growing sector and a number of contributions in this SI are focusing on this area [6–8]. These articles by Alois Jungbauer et al. [6] and the accompanying Commentary by Ajoy Velayudhan [7] and the article by Bernt Nilsson et al. [8] discuss various aspects of downstream processing in recombinant antibody manufacturing and aggregation prediction. In addition, bio-
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
process manufacturing is represented in this SI, with contributions on metabolic modelling and metabolism [9–10], i.e. by presenting the first genome-scale model of the milk yeast Kluyveromyces lactis by Oscar Dias et al. [9] and the article by Alvaro Lara et al. [10] on overflow metabolism in aerobic culture of E. coli, to the development of new production devices by Nicolas Szita et al. [11], or methods of process development through effective analytical screening methods by Linda Otten [12]. The Special Issue includes a variety of emerging technologies and methods suitable for rapid process development. The SI shows advances in industrial biotechnology in the European arena, while describing a variety of emerging technologies and methods suitable for rapid process development or improved product synthesis and purification. These innovations will increase the economic viability of the described bioprocesses. This SI could not have been compiled without the input of our valued contributors, and we thank them for their willingness to contribute to this SI. We are also most indebted to the peer reviewers for their critical comments. Most importantly, this SI would not have been realized without the continuous support and encouragement of Judy Peng and Uta Göbel, who were essential for the realization of the SI. We would like to express our sincere thanks to them: Judy and Uta, thank you for dealing with us.
711
Biotechnology Journal
Biotechnol. J. 2014, 9, 711–712 www.biotecvisions.com
www.biotechnology-journal.com
[4]
Dr. Jarka Glassey, Newcastle University, Newcastle upon Tyne, UK [5]
[6]
Dr. Marcel Ottens, Department of Biotechnology, Delft University of Technology, The Netherlands
References [1] Ferreira, G. and Jungbauer, A., Editorial: ESBES – European Society of Biochemical Engineering Sciences. Biotechnol. J. 2013, 8, 634–635. [2] Formenti, L.R., Nørregaard, A., Bolic, A., Quintanilla Hernandez, D. et al., Challenges in industrial fermentation technology research. Biotechnol. J. 2014, 9, 727–738. [3] von Stosch, M., Davy, S., Francois, K., Galvanauskas, V. et al., Hybrid modeling for quality by design and PAT – benefits and
712
[7]
[8]
[9]
challenges of applications in biopharmaceutical industry. Biotechnol. J. 2014, 9, 719–726. Hariskos, I., Posten, C., Biorefinery of microalgae – opportunities and constraints for different production scenarios. Biotechnol. J. 2014, 9, 739–752. Falano, T., Jeswani, H.K. and Azapagic, A., Assessing the environmental sustainability of ethanol from integrated biorefineries. Biotechnol. J. 2014, 9, 753–765. Hammerschmidt, N., Tscheliessnig, A., Sommer, R., Helk, B. and Jungbauer, A., Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation. Biotechnol. J. 2014, 9, 766–775. Velayudhan, A., Continuous antibody purification using precipitation: An important step forward. Biotechnol. J. 2014, 9, 717–718. Ojala, F., Degerman, M., Hansen T.B., Hansen, E.B., Nilsson, B., Prediction of IgG1 aggregation in solution. Biotechnol. J. 2014, 9, 800–804. Dias O., Pereira, R., Gombert, A.K., Ferreira, E.C., Rocha, I., iOD907, the first genome-scale metabolic model for the milk yeast Kluyveromyces lactis. Biotechnol. J. 2014, 9, 776–790.
Jarka Glassey and Marcel Ottens
[10] Pablos, T. E., Sigala, J. C., Le Borgne, S., Lara, A.R., Aerobic expression of Vitreoscilla hemoglobin efficiently reduces overflow metabolism in Escherichia coli. Biotechnol. J. 2014, 9, 791–799. [11] Macown, R. J., Veraitch, F.S., Szita, N., Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Biotechnol. J. 2014, 9, 805–813. [12] Hiseni, A., Medici, R., Arends, I. W.C.E., Otten, L.G., Enzymatic hydration activity assessed by selective spectrophotometric detection of alcohols: A novel screening assay using oleate hydratase as a model enzyme. Biotechnol. J. 2014, 9, 814–821.
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Biotechnol. J. 2014, 9, 711–712
DOI 10.1002/biot.201400304
www.biotechnology-journal.com
Editorial: Industrial biotechnology – Technologies and methods for rapid process development
T
he world is faced with significant challenges in securing the supply of energy, transportation fuels, food as well as high and low value chemicals. At the same time, people are aiming to improve their living standard regarding nutrition and health. Industrial biotechnology plays a key role in finding solutions for these challenges. At the 2nd European Conference on Applied Biotechnology (ECAB2) in The Hague, The Netherlands, April 2013, it was clear that industrial biotechnology is a growing area. The ECAB2 was held successfully in conjunction with the 9th European Conference on Chemical Engineering (ECCE9) and attracted ~1900 attendees from academia and industry around the world. Many key areas of contemporary industrial biotechnology were highlighted at the conference: biomedical engineering (e.g. cell and tissue engineering), classical biotechnology (e.g. biocatalysis, systems biotechnology, metabolic engineering, the cell factory, proteomics and biotransformation), bioreactor engineering (bioreactors, fermentation technology, fermentation control), analytical technologies (e.g. PAT, bio-sensors, high-throughput screening), separation and downstream processing (e.g. affinity separations, chromatography, membrane technology), renewable energy and feedstock (e.g. bioenergy, biorefineries, renewables, biofuels, algae, marine biotechnology, bio-based products, biomass process technology). The ECAB is a biannual conference organized by the European Society of Biochemical Engineering Science, the ESBES, whose foundation was celebrated at the ECAB2 [1].
This Special Issue (SI) compiles a selection of invited key contributions, original research papers as well as a selection of reviews and perspectives, describing innovative approaches in industrial biotechnology. Two articles by Krist Gernaey et al. [2] and Jarka Glassey et al. [3] offer perspectives on the state-ofthe-art in hybrid modelling in biopharmaceutical manufacturing and in industrial fermentation technology, respectively. They highlight the specific challenges researchers in industry and academia are facing and offer recommendations on research and technology transfer. Contributions by Ioanna Hariskos and Clemens Posten [4] and Adisa Azapagic et al. [5] focus on important areas of biorefinery, reviewing opportunities and constraints for biorefining various products from microalgae, discussing the factors influencing the potential success of such processes and assessing the environmental sustainability of ethanol from biorefineries, respectively. Industrial biotechnology plays a key role in finding solutions for current worldwide challenges. Biopharmaceutical manufacturing is a rapidly growing sector and a number of contributions in this SI are focusing on this area [6–8]. These articles by Alois Jungbauer et al. [6] and the accompanying Commentary by Ajoy Velayudhan [7] and the article by Bernt Nilsson et al. [8] discuss various aspects of downstream processing in recombinant antibody manufacturing and aggregation prediction. In addition, bio-
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
process manufacturing is represented in this SI, with contributions on metabolic modelling and metabolism [9–10], i.e. by presenting the first genome-scale model of the milk yeast Kluyveromyces lactis by Oscar Dias et al. [9] and the article by Alvaro Lara et al. [10] on overflow metabolism in aerobic culture of E. coli, to the development of new production devices by Nicolas Szita et al. [11], or methods of process development through effective analytical screening methods by Linda Otten [12]. The Special Issue includes a variety of emerging technologies and methods suitable for rapid process development. The SI shows advances in industrial biotechnology in the European arena, while describing a variety of emerging technologies and methods suitable for rapid process development or improved product synthesis and purification. These innovations will increase the economic viability of the described bioprocesses. This SI could not have been compiled without the input of our valued contributors, and we thank them for their willingness to contribute to this SI. We are also most indebted to the peer reviewers for their critical comments. Most importantly, this SI would not have been realized without the continuous support and encouragement of Judy Peng and Uta Göbel, who were essential for the realization of the SI. We would like to express our sincere thanks to them: Judy and Uta, thank you for dealing with us.
711
Biotechnology Journal
Biotechnol. J. 2014, 9, 711–712 www.biotecvisions.com
www.biotechnology-journal.com
[4]
Dr. Jarka Glassey, Newcastle University, Newcastle upon Tyne, UK [5]
[6]
Dr. Marcel Ottens, Department of Biotechnology, Delft University of Technology, The Netherlands
References [1] Ferreira, G. and Jungbauer, A., Editorial: ESBES – European Society of Biochemical Engineering Sciences. Biotechnol. J. 2013, 8, 634–635. [2] Formenti, L.R., Nørregaard, A., Bolic, A., Quintanilla Hernandez, D. et al., Challenges in industrial fermentation technology research. Biotechnol. J. 2014, 9, 727–738. [3] von Stosch, M., Davy, S., Francois, K., Galvanauskas, V. et al., Hybrid modeling for quality by design and PAT – benefits and
712
[7]
[8]
[9]
challenges of applications in biopharmaceutical industry. Biotechnol. J. 2014, 9, 719–726. Hariskos, I., Posten, C., Biorefinery of microalgae – opportunities and constraints for different production scenarios. Biotechnol. J. 2014, 9, 739–752. Falano, T., Jeswani, H.K. and Azapagic, A., Assessing the environmental sustainability of ethanol from integrated biorefineries. Biotechnol. J. 2014, 9, 753–765. Hammerschmidt, N., Tscheliessnig, A., Sommer, R., Helk, B. and Jungbauer, A., Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation. Biotechnol. J. 2014, 9, 766–775. Velayudhan, A., Continuous antibody purification using precipitation: An important step forward. Biotechnol. J. 2014, 9, 717–718. Ojala, F., Degerman, M., Hansen T.B., Hansen, E.B., Nilsson, B., Prediction of IgG1 aggregation in solution. Biotechnol. J. 2014, 9, 800–804. Dias O., Pereira, R., Gombert, A.K., Ferreira, E.C., Rocha, I., iOD907, the first genome-scale metabolic model for the milk yeast Kluyveromyces lactis. Biotechnol. J. 2014, 9, 776–790.
Jarka Glassey and Marcel Ottens
[10] Pablos, T. E., Sigala, J. C., Le Borgne, S., Lara, A.R., Aerobic expression of Vitreoscilla hemoglobin efficiently reduces overflow metabolism in Escherichia coli. Biotechnol. J. 2014, 9, 791–799. [11] Macown, R. J., Veraitch, F.S., Szita, N., Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Biotechnol. J. 2014, 9, 805–813. [12] Hiseni, A., Medici, R., Arends, I. W.C.E., Otten, L.G., Enzymatic hydration activity assessed by selective spectrophotometric detection of alcohols: A novel screening assay using oleate hydratase as a model enzyme. Biotechnol. J. 2014, 9, 814–821.
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
