Acta haemat. 58: 312-317 (1977)
Effect of Cancer Chemotherapy Drugs on Platelet Aggregation in Children G. H icsonmez and M. B uylkpamukcu Hacettepe University, School of Medicine and Hacettepe Children’s Medical Center, Ankara
Key Words: Cancer chemotherapy drugs • Platelet aggregation Abstract. The effect of vincristine (VCR), cytoxan and actinomycin-D on plate let aggregation was studied in 30 children with solid tumors. 2 h after administration of these drugs, a statistically insignificant reduction in the primary wave of aggrega tion was observed with the exception of ADP-induced aggregation after VCR injec tion. Unobtainable secondary wave aggregation was seen in 28, 33 and 40°/o of the patients after administration of VCR, cytoxan and actinomycin-D, respectively. However, none of the patients had clinical bleeding. It was concluded that after the intravenous administration of therapeutic dosages of these drugs, the bleeding tend ency caused by inhibition of aggregation is not to be expected.
Cytotoxic drugs are used extensively in the treatment of malignant dis ease and some have been shown to have an inhibitory effect on platelet aggregation in vitro [5, 6, 10]. Although an in vitro effect of some cancer chemotherapy drugs shows an in vivo correlation with animal studies [5], this has not been clearly shown for human beings. In this paper we would like to show the influence of vincristine (VCR), cytoxan and actinomycin-D on platelet aggregation function in patients who had solid tumors.
In this study 30 children (20 males, aged 2-15 years; 10 females, aged 5-9 years) with a variety of solid tumors who had received chemotherapy previously were studied. However, none of the patients had had any medications, including cytotoxic drugs, aspirin or others known to interfere with platelet function, during the month prior to the study and had no evidence of bleeding or infection. The type of tumors in the patients studied is shown in table I. Venous blood samples were obtained from patients before and 2 h after intrave nous injections of cytotoxic drugs. The intravenous dosage of VCR, cytoxan and ac-
Downloaded by: Thomas Jefferson University Scott Library 147.140.27.100 - 5/31/2018 8:36:54 PM
Materials and Method
H icsonmez/B uyukpamukcu
313
tinomycin-D used in this study was, 0.05, 25 mg/kg and 5 /
Effect of Cancer Chemotherapy Drugs on Platelet Aggregation in Children G. H icsonmez and M. B uylkpamukcu Hacettepe University, School of Medicine and Hacettepe Children’s Medical Center, Ankara
Key Words: Cancer chemotherapy drugs • Platelet aggregation Abstract. The effect of vincristine (VCR), cytoxan and actinomycin-D on plate let aggregation was studied in 30 children with solid tumors. 2 h after administration of these drugs, a statistically insignificant reduction in the primary wave of aggrega tion was observed with the exception of ADP-induced aggregation after VCR injec tion. Unobtainable secondary wave aggregation was seen in 28, 33 and 40°/o of the patients after administration of VCR, cytoxan and actinomycin-D, respectively. However, none of the patients had clinical bleeding. It was concluded that after the intravenous administration of therapeutic dosages of these drugs, the bleeding tend ency caused by inhibition of aggregation is not to be expected.
Cytotoxic drugs are used extensively in the treatment of malignant dis ease and some have been shown to have an inhibitory effect on platelet aggregation in vitro [5, 6, 10]. Although an in vitro effect of some cancer chemotherapy drugs shows an in vivo correlation with animal studies [5], this has not been clearly shown for human beings. In this paper we would like to show the influence of vincristine (VCR), cytoxan and actinomycin-D on platelet aggregation function in patients who had solid tumors.
In this study 30 children (20 males, aged 2-15 years; 10 females, aged 5-9 years) with a variety of solid tumors who had received chemotherapy previously were studied. However, none of the patients had had any medications, including cytotoxic drugs, aspirin or others known to interfere with platelet function, during the month prior to the study and had no evidence of bleeding or infection. The type of tumors in the patients studied is shown in table I. Venous blood samples were obtained from patients before and 2 h after intrave nous injections of cytotoxic drugs. The intravenous dosage of VCR, cytoxan and ac-
Downloaded by: Thomas Jefferson University Scott Library 147.140.27.100 - 5/31/2018 8:36:54 PM
Materials and Method
H icsonmez/B uyukpamukcu
313
tinomycin-D used in this study was, 0.05, 25 mg/kg and 5 /
