J Rehabil Med 2014; 46: 1050–1054
Short Communication
Effect of interval training on cognitive functionING and cerebral oxygenation in obese patients: a pilot study Joffrey Drigny, MSc1, Vincent Gremeaux, MD, PhD1–3,4, Olivier Dupuy, PhD1,5–7, Mathieu Gayda, PhD1–3, Louis Bherer, PhD5,6, Martin Juneau, MD1–3 and Anil Nigam, MD1–3 From the 1Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), 2Research Center, Montreal Heart Institute and “Université de Montréal”, 3Department of Medicine, Faculty of Medicine, “Université de Montréal”, Montreal, Canada, 4Plateforme d’investigation technologique, INSERM CIC 1432, CHU Dijon, Dijon, France, 5PERFORM Centre, Department of Psychology, Concordia University, and 6Laboratoire LESCA, Centre de Recherche de l’Institut Universitaire de Gériatrie de Montreal, Montréal, Québec, Canada and 7Faculté des Sciences du Sport, Laboratoire MOVE, Université de Poitiers, Poitiers, France
Objective: To assess the effect of a 4-month high-intensity interval training programme on cognitive functioning, cerebral oxygenation, central haemodynamic and cardiometabolic parameters and aerobic capacity in obese patients. Methods: Cognitive functioning, cerebral oxygenation, central haemodynamic, cardiometabolic and exercise para meters were measured before and after a 4-month highintensity interval training programme in 6 obese patients (mean age 49 years (standard deviation 8), fat mass percentage 31 ± 7%). Results: Body composition (body mass, total and trunk fat mass, waist circumference) and fasting insulin were im. proved after the programme (p 60 rpm. Peak power output (PPO) was defined as the power output reached at the last fully completed stage. Gas exchange (Oxycon Pro, Jaegger, Germany) and central haemodynamic variables (bioimpedancemetry; Physioflow Enduro, Manatec Biomedical, Paris,
1051
France) were measured for 3 min at rest, during exercise and during 5-min recovery, and were averaged every 15 s. Electrocardigram (ECG) (Marquette, Missouri, USA) and blood pressure measurements were . monitored during the test. The maximal average V O value recorded 2 . during exercise was considered as the VO2peak. The ventilatory threshold was determined using a combination of the V-slope, ventilatory equivalents and end-tidal oxygen pressure methods. Cerebral oxygenation. Cerebral oxygenation was measured using near-infrared spectroscopy (NIRS) system (Oxymon Mk III, Artinis, The Netherlands) during exercise (9). Optodes were placed on the left prefrontal cortical area between Fp1 and Fp3, according to the modified international electroencephalogram (EEG) 10–20 system, with an inter-optode distance of 4.5 cm and signal sampling of 10 Hz. Relative concentration changes (Δµmol) were measured from resting baseline of oxyhaemoglobin (Δ[HbO 2]), deoxyhaemoglobin (Δ[HHb]) and total haemoglobin (Δ[HbTot] = [HbO2] + [HHb]). The baseline period was set at the end of the 3-min resting period, defined as 0 µmol (10). Statistical analysis Data were expressed as mean and SD. Statistical differences were localized using Wilcoxon’s signed-rank test, with a p-value
Short Communication
Effect of interval training on cognitive functionING and cerebral oxygenation in obese patients: a pilot study Joffrey Drigny, MSc1, Vincent Gremeaux, MD, PhD1–3,4, Olivier Dupuy, PhD1,5–7, Mathieu Gayda, PhD1–3, Louis Bherer, PhD5,6, Martin Juneau, MD1–3 and Anil Nigam, MD1–3 From the 1Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), 2Research Center, Montreal Heart Institute and “Université de Montréal”, 3Department of Medicine, Faculty of Medicine, “Université de Montréal”, Montreal, Canada, 4Plateforme d’investigation technologique, INSERM CIC 1432, CHU Dijon, Dijon, France, 5PERFORM Centre, Department of Psychology, Concordia University, and 6Laboratoire LESCA, Centre de Recherche de l’Institut Universitaire de Gériatrie de Montreal, Montréal, Québec, Canada and 7Faculté des Sciences du Sport, Laboratoire MOVE, Université de Poitiers, Poitiers, France
Objective: To assess the effect of a 4-month high-intensity interval training programme on cognitive functioning, cerebral oxygenation, central haemodynamic and cardiometabolic parameters and aerobic capacity in obese patients. Methods: Cognitive functioning, cerebral oxygenation, central haemodynamic, cardiometabolic and exercise para meters were measured before and after a 4-month highintensity interval training programme in 6 obese patients (mean age 49 years (standard deviation 8), fat mass percentage 31 ± 7%). Results: Body composition (body mass, total and trunk fat mass, waist circumference) and fasting insulin were im. proved after the programme (p 60 rpm. Peak power output (PPO) was defined as the power output reached at the last fully completed stage. Gas exchange (Oxycon Pro, Jaegger, Germany) and central haemodynamic variables (bioimpedancemetry; Physioflow Enduro, Manatec Biomedical, Paris,
1051
France) were measured for 3 min at rest, during exercise and during 5-min recovery, and were averaged every 15 s. Electrocardigram (ECG) (Marquette, Missouri, USA) and blood pressure measurements were . monitored during the test. The maximal average V O value recorded 2 . during exercise was considered as the VO2peak. The ventilatory threshold was determined using a combination of the V-slope, ventilatory equivalents and end-tidal oxygen pressure methods. Cerebral oxygenation. Cerebral oxygenation was measured using near-infrared spectroscopy (NIRS) system (Oxymon Mk III, Artinis, The Netherlands) during exercise (9). Optodes were placed on the left prefrontal cortical area between Fp1 and Fp3, according to the modified international electroencephalogram (EEG) 10–20 system, with an inter-optode distance of 4.5 cm and signal sampling of 10 Hz. Relative concentration changes (Δµmol) were measured from resting baseline of oxyhaemoglobin (Δ[HbO 2]), deoxyhaemoglobin (Δ[HHb]) and total haemoglobin (Δ[HbTot] = [HbO2] + [HHb]). The baseline period was set at the end of the 3-min resting period, defined as 0 µmol (10). Statistical analysis Data were expressed as mean and SD. Statistical differences were localized using Wilcoxon’s signed-rank test, with a p-value
