Scandinavian Journal of Clinical and Laboratory Investigation
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia Y. Levy, L. Klein, M. Aviram, G. J. Brook & U. Cogan To cite this article: Y. Levy, L. Klein, M. Aviram, G. J. Brook & U. Cogan (1992) Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia, Scandinavian Journal of Clinical and Laboratory Investigation, 52:7, 671-677, DOI: 10.3109/00365519209115512 To link to this article: http://dx.doi.org/10.3109/00365519209115512
Published online: 08 Jul 2009.
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Date: 18 April 2016, At: 22:27
Scand J Clin Lab Invest 1992: 52: 671-677
Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia Y. LEVY, L. KLEIN, M . A V I R A M , G . J . B R O O K & U . C O G A N *
Downloaded by [UNSW Library] at 22:27 18 April 2016
Lipid Research Unit, Rambam Medical Center and Rappaport Institute for Research in Medical Sciences and Technion Faculty of Medicine, and *Department of Food Engineering and Biotechnology Technion Institute of Technology, Haifa, Israel.
Levy Y, Klein L, Aviram M, Brook GJ, Cogan U. Effect of lovastatin and lipoprotein fluidity in patients with hypercholesterolaemia. Scand J Clin Lab Invest 1992; 52: 671-677. Lovastatin was administered to six hypercholesterolaemic patients (mean plasma cholesterol 450 mg dl-I). Plasma lipoproteins (VLDL, LDL, and HDL) were separated before and following 7 and 12 weeks treatment with lovastatin. Fluidity was quantified by fluorescence polarization measurements using 1,6diphenyl 1,3,5 hexatriene (DPH) as the fluorescent probe. Lovastatin treatment resulted in a significant reduction of total plasma cholesterol, LDL cholesterol and VLDL cholesterol (-417'0, -44%, -68%, respectively). Fluidity measurements showed significant (p
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia Y. Levy, L. Klein, M. Aviram, G. J. Brook & U. Cogan To cite this article: Y. Levy, L. Klein, M. Aviram, G. J. Brook & U. Cogan (1992) Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia, Scandinavian Journal of Clinical and Laboratory Investigation, 52:7, 671-677, DOI: 10.3109/00365519209115512 To link to this article: http://dx.doi.org/10.3109/00365519209115512
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 2
View related articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iclb20 Download by: [UNSW Library]
Date: 18 April 2016, At: 22:27
Scand J Clin Lab Invest 1992: 52: 671-677
Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia Y. LEVY, L. KLEIN, M . A V I R A M , G . J . B R O O K & U . C O G A N *
Downloaded by [UNSW Library] at 22:27 18 April 2016
Lipid Research Unit, Rambam Medical Center and Rappaport Institute for Research in Medical Sciences and Technion Faculty of Medicine, and *Department of Food Engineering and Biotechnology Technion Institute of Technology, Haifa, Israel.
Levy Y, Klein L, Aviram M, Brook GJ, Cogan U. Effect of lovastatin and lipoprotein fluidity in patients with hypercholesterolaemia. Scand J Clin Lab Invest 1992; 52: 671-677. Lovastatin was administered to six hypercholesterolaemic patients (mean plasma cholesterol 450 mg dl-I). Plasma lipoproteins (VLDL, LDL, and HDL) were separated before and following 7 and 12 weeks treatment with lovastatin. Fluidity was quantified by fluorescence polarization measurements using 1,6diphenyl 1,3,5 hexatriene (DPH) as the fluorescent probe. Lovastatin treatment resulted in a significant reduction of total plasma cholesterol, LDL cholesterol and VLDL cholesterol (-417'0, -44%, -68%, respectively). Fluidity measurements showed significant (p
