European Journal of Clinical Investigation (1 977) 7 , 3 19-320
SHORT COMMUNICATION
Effect of physical exercise on erythrocyte lipids, biliary cholesterol and bile lithogenicity in rats VLADO SLMKO & ROBERT KELLEY, Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio Received 31 December 1976 and in revised form 30 May 1977
Abstract. Male Wistar rats were exercised (E) by daily
1 h swimming for 24 days. Sedentary controls ( S ) were caged individually. Bile analysis at the end of the experiment (24 h after the last exercise) showed a decrease in bile cholesterol (CH) ( K 0 . 0 2 ) and phospholipids (PL) (KO.01) in the exercising animals, but no significant change in the bile acids (BA). These changes in the exercising rats resulted in a decreased CH saturation of bile: in an improvement in the (BA t PL)/CH ratio (P=O.OS) and a trend to a decrease in the per cent saturation of bile CH. Exercise did not affect the bile flow or bile acid flux rate. Exercise decreased erythrocyte phospholipids (P
SHORT COMMUNICATION
Effect of physical exercise on erythrocyte lipids, biliary cholesterol and bile lithogenicity in rats VLADO SLMKO & ROBERT KELLEY, Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio Received 31 December 1976 and in revised form 30 May 1977
Abstract. Male Wistar rats were exercised (E) by daily
1 h swimming for 24 days. Sedentary controls ( S ) were caged individually. Bile analysis at the end of the experiment (24 h after the last exercise) showed a decrease in bile cholesterol (CH) ( K 0 . 0 2 ) and phospholipids (PL) (KO.01) in the exercising animals, but no significant change in the bile acids (BA). These changes in the exercising rats resulted in a decreased CH saturation of bile: in an improvement in the (BA t PL)/CH ratio (P=O.OS) and a trend to a decrease in the per cent saturation of bile CH. Exercise did not affect the bile flow or bile acid flux rate. Exercise decreased erythrocyte phospholipids (P
