Clin Physiol Funct Imaging (2015) 35, pp134–141
doi: 10.1111/cpf.12138
Effect of positive end-expiratory pressure on acoustic wave propagation in experimental porcine lung injury €sa €nen1, Michael E. Nemergut2 and Noam Gavriely3 Jukka Ra 1
Department of Anesthesiology, H. Lee Moffitt Cancer Center, Tampa, FL, 2Departments of Anesthesiology and Pediatrics, Mayo Foundation for Education and Research, Rochester, MN, USA and 3Technion – Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel
Summary Correspondence Jukka R€as€anen, Department of Anesthesiology, H. Lee Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA E-mail: [email protected]
Accepted for publication Received 11 October 2013; accepted 17 January 2014
Key words acoustics; acute lung injury; pulmonary oedema; respiratory sounds; transit time
To evaluate the effect of positive end-expiratory pressure (PEEP) on sound propagation through injured lungs, we injected a multifrequency broad-band sound signal into the airway of eight anesthetized, intubated and mechanically ventilated pigs, while recording transmitted sound at three locations bilaterally on the chest wall. Oleic acid injections effected a severe pulmonary oedema predominately in the dependent lung regions, with an average increase in venous admixture from 19 15 to 59 14% (P
doi: 10.1111/cpf.12138
Effect of positive end-expiratory pressure on acoustic wave propagation in experimental porcine lung injury €sa €nen1, Michael E. Nemergut2 and Noam Gavriely3 Jukka Ra 1
Department of Anesthesiology, H. Lee Moffitt Cancer Center, Tampa, FL, 2Departments of Anesthesiology and Pediatrics, Mayo Foundation for Education and Research, Rochester, MN, USA and 3Technion – Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel
Summary Correspondence Jukka R€as€anen, Department of Anesthesiology, H. Lee Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA E-mail: [email protected]
Accepted for publication Received 11 October 2013; accepted 17 January 2014
Key words acoustics; acute lung injury; pulmonary oedema; respiratory sounds; transit time
To evaluate the effect of positive end-expiratory pressure (PEEP) on sound propagation through injured lungs, we injected a multifrequency broad-band sound signal into the airway of eight anesthetized, intubated and mechanically ventilated pigs, while recording transmitted sound at three locations bilaterally on the chest wall. Oleic acid injections effected a severe pulmonary oedema predominately in the dependent lung regions, with an average increase in venous admixture from 19 15 to 59 14% (P
