Klinische Wochenschrift
Klin Wochenschr (1991) 69 : 486490 002321739100128C
9 Springer-Verlag 1991
Effect of Somatostatin on Kidney Function and Vasoactive Hormone Systems in Healthy Subjects T. Tulassay 1, Z. Tulassay 1, W. Rascher 3, L. SziJcs 2, H.W. Seyberth 4, and I. Nagy 2 i 1st Department of Pediatrics and Internal Medicine, Semmelweis University Medical School, Budapest; 2 1st Department of Pediatrics Postgraduate Medical University, Budapest; 3 University Children's Hospital, Essen; 4 University Children's Hospital, Marburg
Summary. The acute effects of i.v. somatostatin (250 mcg bolus followed by 250 mcg/h continuous infusion for two hours) on renal hemodynamics, renal electrolyte and water handling, and urinary excretion of catecholamines and prostaglandins, as well as on plasma concentrations of arginine vasopressin, atrial natriuretic factor, norepinephrine, epinephrine, dopamine, glucagon, and plasma renin activity were studied in seven normal subjects. Somatostatin decreased effective renal plasma flow and glomerular filtration rate, osmotic and free water clearances, urine volume, and sodium and potassium excretion, while urinary osmolality, fractional excretion of sodium, and phosphate excretion increased significantly. Plasma concentrations of arginine vasopressin, atrial natriuretic factor, norepinephrine, epinephrine, and dopamine remained unchanged, while plasma renin activity (3.0 _+0.25 vs 2.4 _+0.2 ng AngI/ml/h; p < 0.01) and glucagon levels (40+_ 11 vs 20_+ 16 pg/ml; p
Klin Wochenschr (1991) 69 : 486490 002321739100128C
9 Springer-Verlag 1991
Effect of Somatostatin on Kidney Function and Vasoactive Hormone Systems in Healthy Subjects T. Tulassay 1, Z. Tulassay 1, W. Rascher 3, L. SziJcs 2, H.W. Seyberth 4, and I. Nagy 2 i 1st Department of Pediatrics and Internal Medicine, Semmelweis University Medical School, Budapest; 2 1st Department of Pediatrics Postgraduate Medical University, Budapest; 3 University Children's Hospital, Essen; 4 University Children's Hospital, Marburg
Summary. The acute effects of i.v. somatostatin (250 mcg bolus followed by 250 mcg/h continuous infusion for two hours) on renal hemodynamics, renal electrolyte and water handling, and urinary excretion of catecholamines and prostaglandins, as well as on plasma concentrations of arginine vasopressin, atrial natriuretic factor, norepinephrine, epinephrine, dopamine, glucagon, and plasma renin activity were studied in seven normal subjects. Somatostatin decreased effective renal plasma flow and glomerular filtration rate, osmotic and free water clearances, urine volume, and sodium and potassium excretion, while urinary osmolality, fractional excretion of sodium, and phosphate excretion increased significantly. Plasma concentrations of arginine vasopressin, atrial natriuretic factor, norepinephrine, epinephrine, and dopamine remained unchanged, while plasma renin activity (3.0 _+0.25 vs 2.4 _+0.2 ng AngI/ml/h; p < 0.01) and glucagon levels (40+_ 11 vs 20_+ 16 pg/ml; p
