Performance
in Men After 6hyocardia
Infarction
StZle Barvik, MD, Kenneth Dickstein, MD, Torbjgrn Aarsland, RN, and Harald Vik-Mo, MD PhD
The effect of the nonselective @blocker timolol on maxbnal cardiopulmonary exercise performance was evaluated in 26 men with previous myocardlal infarctton without effort angina (mean age 63 f 8 years). Patients were randomized to placebo or tfmotol(10 mg twice daily) for 4 weeks and then crossed over to the alternative therapy in a doubfe-Mind manner. At the completion of each treatment period, patients underwent symptom-limited maximal cardfopubnonary exercise on a cycle ergometer. Exercise time, heart rate, oxygen consumption (QOs), oxygen (02) pulse and respiratory exchange ratio were measured at peak exercise and at a submaximal exercise level defined at a respiratory exchange ratio of 1.66. Timotol treatment reduced peak heart rate from 163 f 11 to 102 f 14 beats/min (-33%, p
in Men After 6hyocardia
Infarction
StZle Barvik, MD, Kenneth Dickstein, MD, Torbjgrn Aarsland, RN, and Harald Vik-Mo, MD PhD
The effect of the nonselective @blocker timolol on maxbnal cardiopulmonary exercise performance was evaluated in 26 men with previous myocardlal infarctton without effort angina (mean age 63 f 8 years). Patients were randomized to placebo or tfmotol(10 mg twice daily) for 4 weeks and then crossed over to the alternative therapy in a doubfe-Mind manner. At the completion of each treatment period, patients underwent symptom-limited maximal cardfopubnonary exercise on a cycle ergometer. Exercise time, heart rate, oxygen consumption (QOs), oxygen (02) pulse and respiratory exchange ratio were measured at peak exercise and at a submaximal exercise level defined at a respiratory exchange ratio of 1.66. Timotol treatment reduced peak heart rate from 163 f 11 to 102 f 14 beats/min (-33%, p
