HHS Public Access Author manuscript Author Manuscript
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2017 January 01. Published in final edited form as: J Acquir Immune Defic Syndr. 2016 January 1; 71(1): 38–46. doi:10.1097/QAI.0000000000000803.
Effective Treatment of Depressive Disorders in Medical Clinics for Adolescents and Young Adults living with HIV: A controlled trial
Author Manuscript
Larry K. Brown1, Betsy D. Kennard2, Graham J. Emslie2, Taryn L. Mayes2, Laura B. Whiteley1, James Bethel3, Jiahong Xu3, Sarah Thornton3, Mary R. Tanney4, Linda A. Hawkins4, Patricia A. Garvie5, Geetha A. Subramaniam6, Carol J. Worrell7, Laura W. Stoff1, and Adolescent Trials Network for HIV/AIDS Interventions 1Rhode
Island Hospital; Alpert Medical School of Brown University
2University 3Westat, 4The
of Texas Southwestern Medical Center at Dallas
Rockville, MD
Children’s Hospital of Philadelphia, Philadelphia PA
5Children’s 6NIDA
Diagnostic & Treatment Center, Fort Lauderdale, FL
Center for Clinical Trials Network, Bethesda, MD
7Eunice
Kennedy Shriver National Institute of Child Health and Human Development, Bethesda,
MD
Author Manuscript
Abstract Objective—Preliminary test of a manualized, measurement-guided treatment for depression for adolescents and young adults in care at four sites of the Adolescent Trials Network for HIV/AIDS Interventions (ATN). Design—The U.S. sites were randomly assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB) tailored for youth living with HIV (YLWH) or to treatment as usual (TAU).
Author Manuscript
Methods—Youth at TAU sites had access to therapists and medication management as needed. COMB site clinicians were trained in the manualized intervention and participated in supervision calls to monitor intervention fidelity. Results—Over the course of the study with 44 participants, those in COMB, compared to those in TAU, reported fewer depressive symptoms, p
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2017 January 01. Published in final edited form as: J Acquir Immune Defic Syndr. 2016 January 1; 71(1): 38–46. doi:10.1097/QAI.0000000000000803.
Effective Treatment of Depressive Disorders in Medical Clinics for Adolescents and Young Adults living with HIV: A controlled trial
Author Manuscript
Larry K. Brown1, Betsy D. Kennard2, Graham J. Emslie2, Taryn L. Mayes2, Laura B. Whiteley1, James Bethel3, Jiahong Xu3, Sarah Thornton3, Mary R. Tanney4, Linda A. Hawkins4, Patricia A. Garvie5, Geetha A. Subramaniam6, Carol J. Worrell7, Laura W. Stoff1, and Adolescent Trials Network for HIV/AIDS Interventions 1Rhode
Island Hospital; Alpert Medical School of Brown University
2University 3Westat, 4The
of Texas Southwestern Medical Center at Dallas
Rockville, MD
Children’s Hospital of Philadelphia, Philadelphia PA
5Children’s 6NIDA
Diagnostic & Treatment Center, Fort Lauderdale, FL
Center for Clinical Trials Network, Bethesda, MD
7Eunice
Kennedy Shriver National Institute of Child Health and Human Development, Bethesda,
MD
Author Manuscript
Abstract Objective—Preliminary test of a manualized, measurement-guided treatment for depression for adolescents and young adults in care at four sites of the Adolescent Trials Network for HIV/AIDS Interventions (ATN). Design—The U.S. sites were randomly assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB) tailored for youth living with HIV (YLWH) or to treatment as usual (TAU).
Author Manuscript
Methods—Youth at TAU sites had access to therapists and medication management as needed. COMB site clinicians were trained in the manualized intervention and participated in supervision calls to monitor intervention fidelity. Results—Over the course of the study with 44 participants, those in COMB, compared to those in TAU, reported fewer depressive symptoms, p
