EuropeanJournalof
Nuclear Medicine
Original article
Effects of atrial natriuretic peptide on glomerular filtration rate in essential hypertension: a radionuclide study A l b e r t o C u o c o l o 1, M a s s i m o V o l p e 1, A l e s s a n d r o B r u n o T r i m a r c o 1, a n d M a r c o S a l v a t o r e 1
F. M e l e 2, L u i g i C e l e n t a n o 2, R o n a l d D. N e u m a n n 2,
1 Istituto di Scienze Radiologiche, Cattedra di Medicina Nucleare, 1a Ctinica Medica, 2a Facolt~. di Medicina, Universit& degli Studi di Napoli and 2 Istituto Nazionale dei Tumori, Napoli, Italy Received April 17, revised June 28, 1990
Abstract. A number of studies show that atrial natriuretic peptide (ANP) raises renal sodium excretion with a concomitant increase in glomerular filtration rate (GFR) in both experimental animals and normal humans. Studies using indirect evaluation of G F R have provided less consistent results in hypertensive patients. We studied the effects of intravenously administered (iv) e-human ANP on G F R in patients with hypertension by a radionuclide technique using technetium 99m diethylenetriaminepenta-acetic acid. In six patients (ANP group), G F R was determined under control conditions, during iv ANP (initial bolus of 0.5 gg/kg followed by a 21-rain maintenance infusion at 0.05 l,tg.kg -1. min-1) and during a recovery phase. In six other patients (control group), G F R was determined under control conditions, during saline iv infusion and during recovery. The two groups did not differ with respect to age, sex, basal blood pressure, heart rate or GFR. In the ANP group, the infusion of the peptide induced a significant decrease of mean blood pressure (from 133 + 5 to 120-t-5 mmHg, P
Nuclear Medicine
Original article
Effects of atrial natriuretic peptide on glomerular filtration rate in essential hypertension: a radionuclide study A l b e r t o C u o c o l o 1, M a s s i m o V o l p e 1, A l e s s a n d r o B r u n o T r i m a r c o 1, a n d M a r c o S a l v a t o r e 1
F. M e l e 2, L u i g i C e l e n t a n o 2, R o n a l d D. N e u m a n n 2,
1 Istituto di Scienze Radiologiche, Cattedra di Medicina Nucleare, 1a Ctinica Medica, 2a Facolt~. di Medicina, Universit& degli Studi di Napoli and 2 Istituto Nazionale dei Tumori, Napoli, Italy Received April 17, revised June 28, 1990
Abstract. A number of studies show that atrial natriuretic peptide (ANP) raises renal sodium excretion with a concomitant increase in glomerular filtration rate (GFR) in both experimental animals and normal humans. Studies using indirect evaluation of G F R have provided less consistent results in hypertensive patients. We studied the effects of intravenously administered (iv) e-human ANP on G F R in patients with hypertension by a radionuclide technique using technetium 99m diethylenetriaminepenta-acetic acid. In six patients (ANP group), G F R was determined under control conditions, during iv ANP (initial bolus of 0.5 gg/kg followed by a 21-rain maintenance infusion at 0.05 l,tg.kg -1. min-1) and during a recovery phase. In six other patients (control group), G F R was determined under control conditions, during saline iv infusion and during recovery. The two groups did not differ with respect to age, sex, basal blood pressure, heart rate or GFR. In the ANP group, the infusion of the peptide induced a significant decrease of mean blood pressure (from 133 + 5 to 120-t-5 mmHg, P
