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中国肺癌杂志2013年12月第16卷第12期
·625·
Chin J Lung Cancer, December 2013, Vol.16, No.12
DOI: 10.3779/j.issn.1009-3419.2013.12.02
·基础研究·
西妥昔单抗联合塞来昔布 对肺腺癌细胞KDR和AQP1表达的影响 夏洪刚 叶剑飞 白宏宇 王长利 【摘要】 背景与目的 新辅助化疗是肺癌治疗的新进展,西妥昔单和合塞来昔布均是近年来新辅助化疗的常 用药物,本研究旨在探讨表皮生长因子受体(epithelial growth factor receptor, EGFR)单克隆抗体西妥昔单抗(Cetuximab)联合环氧合酶2(cyclooxygenase-2, COX-2)抑制剂塞来昔布对肺腺癌A549细胞株凋亡和KDR、AQP1表达的影 响。方法 A549细胞培养于RPMI-1640培养液中,实验分为正常对照组、西妥昔单抗1 nmol/L组、塞来昔布25 μmol/L 组、西妥昔单抗1 nmol/L+塞来昔布25 μmol/L组。药物干预细胞48 h后,采用四甲基偶氮唑盐比色法测定细胞抑制 率;采用流式细胞术测定细胞周期分布的变化;用Transwell小室法检测药物处理前后细胞侵袭力的变化。采用RTPCR、Western blot检测KDR、AQP1基因和蛋白的表达情况。结果 西妥昔单抗和塞来昔布对A549细胞增殖有明显的 抑制作用,两制剂联合作用时抑制作用更强(P
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背景与目的 新辅助化疗是肺癌治疗的新进展,西妥昔单和合塞来昔布均是近年来新辅助化疗的常用药物,本研究旨在探讨表皮生长因子受体(epithelial growth factor receptor, EGFR)单克隆抗体西妥昔单抗(Cetuximab)联合环氧合酶2(cyclooxygenase-2, ...
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