104
British Journal of Industrial Medicine 1992;49:104-112
Effects of ethanol and phenobarbital treatments on the pharmacokinetics of toluene in rats Rui-Sheng Wang, Tamie Nakajima Abstract Rats were exposed to toluene at a wide range of concentrations from 50 to 4000 ppm for six hours, and the effects of ethanol and phenobarbital (PB) treatments on the pharmacokinetics of toluene metabolism were investigated. Ethanol treatment influenced toluene metabolism mainly at low exposure concentrations. Thus ethanol accelerated the clearance of toluene from blood only when the blood concentration of toluene was not high (< 360 pM), and ethanol increased hippuric acid (HA) excretion in urine more significantly at low (
British Journal of Industrial Medicine 1992;49:104-112
Effects of ethanol and phenobarbital treatments on the pharmacokinetics of toluene in rats Rui-Sheng Wang, Tamie Nakajima Abstract Rats were exposed to toluene at a wide range of concentrations from 50 to 4000 ppm for six hours, and the effects of ethanol and phenobarbital (PB) treatments on the pharmacokinetics of toluene metabolism were investigated. Ethanol treatment influenced toluene metabolism mainly at low exposure concentrations. Thus ethanol accelerated the clearance of toluene from blood only when the blood concentration of toluene was not high (< 360 pM), and ethanol increased hippuric acid (HA) excretion in urine more significantly at low (
