European Heart Journal (1992) 13, 1380-1386
Effects of impaired lung function and pulmonary regurgitation on maximal exercise capacity in patients with repaired tetralogy of Fallot G. NORGARD, A . BJ0RKHAUG AND H. ViK-MO
KEY WORDS: Tetralogy of Fallot, exercise testing, gas exchange parameters, pulmonary regurgitation, lung function.
Downloaded from https://academic.oup.com/eurheartj/article-abstract/13/10/1380/453794 by Lancaster University user on 11 January 2019
From the Department of Clinical Physiology, Haukeland Hospital, 5021 Bergen, Norway
Long-term haemodynamic results and exercise capacity were studied in 34 patients with tetralogy of Fallot (24 men and 10 women) repaired 100 ± 4-9 (mean ± SD) years previously and compared to 34 healthy matched controls. All subjects were studied by resting spirometry, echocardiography and a symptom limited treadmill exercise test (modified Bruce protocol). The maximal oxygen consumption was 38-2±80 ml. kg~' .min~' in patients and 481 ±8-1 ml. kg'1 .min'' in the control group (P
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Values are mean ± 1 SD when appropriate. BSA = body surface areas; ns = not significant.
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i Table 2 Gas exchange parameters and ventilation during treadmill exercise in tetralogy of Fallot and healthy controls Patients VO 2 (ml.kg-'.min-') rest maximal RQ maximal Breath frequency Minute ventilation VAT (ml. kg"1 .min-1) VAT %
6-3 ±1-9 38-2±8-0 M3±009 48-8± 13-9 62-9± 19-9 23-8±0-6 63-5± 12-9
Controls
P value
5-1 ±1-7 48 1 ±8-1
raildPR(n=12)
VOj(ml.kg-'.min-') Heart rate (beat. min~') RVA(cm2.ra-2) VC(1)
431 ±5-3" 1930 ±6-4 19-6±4 8 3-6± 1-2
41-8±5-7" 187-5±121 21-2±3-8 3-6±I-2
34-4±8-9" 184-3±10-7 24-5 ±5-4 30± 1-4
Values are mean + SD; n = numbers of patients; PR = pulmonary regurgitation; RVA = right ventricular diastohc area; VC = vital capacity (litres); VO2 = maximal oxygen consumption; 1 = significant different from b (P < 005).
(14-7%), and no patients had severe pulmonary stenosis. The presence of pulmonary stenosis did not affect the maximal oxygen consumption. TR was detected in 20 patients (58-8%), in one of whom it was regarded as moderate and in 19 as mild. Maximal oxygen consumption in patients with and without TR was 38-6 + 8-7 and 37-7+_7-3ml. kg" 1 . min"', respectively (ns). The right ventricular diastolic area was 23-4 + 50 and 21-0±4-7 cm2. m " 2 in patients with and without TR (ns). No differences in age, gender, age at surgery, VAT or lung function were found between patients with and without TR.
100
EXERCISE TOLERANCE
Treadmill exercise time was 13-9 ± 1-8 min in patients and 151 + 1-6 min in controls (P < 0005), while treadmill distance was 824+198 m and 974+193 m, respectively (P
Effects of impaired lung function and pulmonary regurgitation on maximal exercise capacity in patients with repaired tetralogy of Fallot G. NORGARD, A . BJ0RKHAUG AND H. ViK-MO
KEY WORDS: Tetralogy of Fallot, exercise testing, gas exchange parameters, pulmonary regurgitation, lung function.
Downloaded from https://academic.oup.com/eurheartj/article-abstract/13/10/1380/453794 by Lancaster University user on 11 January 2019
From the Department of Clinical Physiology, Haukeland Hospital, 5021 Bergen, Norway
Long-term haemodynamic results and exercise capacity were studied in 34 patients with tetralogy of Fallot (24 men and 10 women) repaired 100 ± 4-9 (mean ± SD) years previously and compared to 34 healthy matched controls. All subjects were studied by resting spirometry, echocardiography and a symptom limited treadmill exercise test (modified Bruce protocol). The maximal oxygen consumption was 38-2±80 ml. kg~' .min~' in patients and 481 ±8-1 ml. kg'1 .min'' in the control group (P
20
£
io
c
Values are mean ± 1 SD when appropriate. BSA = body surface areas; ns = not significant.
o
i Table 2 Gas exchange parameters and ventilation during treadmill exercise in tetralogy of Fallot and healthy controls Patients VO 2 (ml.kg-'.min-') rest maximal RQ maximal Breath frequency Minute ventilation VAT (ml. kg"1 .min-1) VAT %
6-3 ±1-9 38-2±8-0 M3±009 48-8± 13-9 62-9± 19-9 23-8±0-6 63-5± 12-9
Controls
P value
5-1 ±1-7 48 1 ±8-1
raildPR(n=12)
VOj(ml.kg-'.min-') Heart rate (beat. min~') RVA(cm2.ra-2) VC(1)
431 ±5-3" 1930 ±6-4 19-6±4 8 3-6± 1-2
41-8±5-7" 187-5±121 21-2±3-8 3-6±I-2
34-4±8-9" 184-3±10-7 24-5 ±5-4 30± 1-4
Values are mean + SD; n = numbers of patients; PR = pulmonary regurgitation; RVA = right ventricular diastohc area; VC = vital capacity (litres); VO2 = maximal oxygen consumption; 1 = significant different from b (P < 005).
(14-7%), and no patients had severe pulmonary stenosis. The presence of pulmonary stenosis did not affect the maximal oxygen consumption. TR was detected in 20 patients (58-8%), in one of whom it was regarded as moderate and in 19 as mild. Maximal oxygen consumption in patients with and without TR was 38-6 + 8-7 and 37-7+_7-3ml. kg" 1 . min"', respectively (ns). The right ventricular diastolic area was 23-4 + 50 and 21-0±4-7 cm2. m " 2 in patients with and without TR (ns). No differences in age, gender, age at surgery, VAT or lung function were found between patients with and without TR.
100
EXERCISE TOLERANCE
Treadmill exercise time was 13-9 ± 1-8 min in patients and 151 + 1-6 min in controls (P < 0005), while treadmill distance was 824+198 m and 974+193 m, respectively (P
