ANIMAL STUDY e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 2714-2719 DOI: 10.12659/MSM.896919
Effects of Montelukast in an Experimental Model of Acute Pancreatitis
Received: 2015.11.30 Accepted: 2016.01.02 Published: 2016.08.01
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
AB 1 AB 1 AB 1 AB 1 AB 2 AB 3
Serkan Angı Hüseyin Eken Erol Kılıç Oktay Karaköse Gürhan Balci Erkan Somuncu
1 Department of General Surgery, Ondokuz Mayıs University, Samsun, Turkey 2 Department of Pathology, Erzincan University, Erzincan, Turkey 3 Department of General Surgery, Erzincan University, Erzincan, Turkey
Corresponding Author: Source of support:
Huseyin Eken, e-mail: [email protected] The stud ywas approved by the Ethics Board of Samsun 19 Mayıs University, School of Medicine (Dated 03.07.2008 and issue number 2008/27)
Background:
We evaluated the hematological, biochemical, and histopathological effects of Montelukast on pancreatic damage in an experimental acute pancreatitis model created by cerulein in rats before and after the induction of pancreatitis. Forty rats were divided into 4 groups with 10 rats each. The study groups were: the Cerulein (C) group, the Cerulein + early Montelukast (CMe) group, the Cerulein + late Montelukast (CMl) group, and the Control group. The pH, pO2, pCO2, HCO3, leukocyte, hematocrit, pancreatic amylase, and lipase values were measured in the arterial blood samples taken immediately before rats were killed. There were statistically significant differences between the C group and the Control group in the values of pancreatic amylase, lipase, blood leukocyte, hematocrit, pH, pO2, pCO2, HCO3, and pancreatic water content, and also in each of the values of edema, inflammation, vacuolization, necrosis, and total histopathological score (P
Effects of Montelukast in an Experimental Model of Acute Pancreatitis
Received: 2015.11.30 Accepted: 2016.01.02 Published: 2016.08.01
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
AB 1 AB 1 AB 1 AB 1 AB 2 AB 3
Serkan Angı Hüseyin Eken Erol Kılıç Oktay Karaköse Gürhan Balci Erkan Somuncu
1 Department of General Surgery, Ondokuz Mayıs University, Samsun, Turkey 2 Department of Pathology, Erzincan University, Erzincan, Turkey 3 Department of General Surgery, Erzincan University, Erzincan, Turkey
Corresponding Author: Source of support:
Huseyin Eken, e-mail: [email protected] The stud ywas approved by the Ethics Board of Samsun 19 Mayıs University, School of Medicine (Dated 03.07.2008 and issue number 2008/27)
Background:
We evaluated the hematological, biochemical, and histopathological effects of Montelukast on pancreatic damage in an experimental acute pancreatitis model created by cerulein in rats before and after the induction of pancreatitis. Forty rats were divided into 4 groups with 10 rats each. The study groups were: the Cerulein (C) group, the Cerulein + early Montelukast (CMe) group, the Cerulein + late Montelukast (CMl) group, and the Control group. The pH, pO2, pCO2, HCO3, leukocyte, hematocrit, pancreatic amylase, and lipase values were measured in the arterial blood samples taken immediately before rats were killed. There were statistically significant differences between the C group and the Control group in the values of pancreatic amylase, lipase, blood leukocyte, hematocrit, pH, pO2, pCO2, HCO3, and pancreatic water content, and also in each of the values of edema, inflammation, vacuolization, necrosis, and total histopathological score (P
