Effects of weight loss on substrate expenditure, and insulin sensitivity Anja

Franssila-Kallunki,

Aila

Rissanen,

Agneta

oxidation, in obese

Ekstrand,

Anne/i

energy individuals13

0//us,

and

LefGroop

ABSTRACT strate oxidation,

To evaluate the effect of weight loss on subenergy expenditure, and insulin sensitivity we

oxidation

studied

subjects

To address this question we examined reduction achieved by a VLCD on different metabolism in obese nondiabetic subjects.

12 obese

(body

and after 6 wk ofa very-low-calorie insulin clamp in combination

weight

decreased

from

105.3

and fat mass from 47.2 glucose disposal during

to 38.4