ECG changes and prognosis of Takotsubo cardiomyopathy Patompong Ungprasert MD, Narat Srivali MD PII: DOI: Reference:
S0735-6757(15)00083-2 doi: 10.1016/j.ajem.2015.02.021 YAJEM 54808
To appear in:
American Journal of Emergency Medicine
Received date: Accepted date:
10 February 2015 11 February 2015
Please cite this article as: Ungprasert Patompong, Srivali Narat, ECG changes and prognosis of Takotsubo cardiomyopathy, American Journal of Emergency Medicine (2015), doi: 10.1016/j.ajem.2015.02.021
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Title page Title: ECG changes and prognosis of Takotsubo cardiomyopathy
RI P
Authors: *Patompong Ungprasert, MD1, Narat Srivali, MD2
T
Article type: Letter to editor
1 Division of rheumatology, Mayo Clinic, Rochester, MN, USA
MA NU
SC
2 Division of pulmonology and critical care medicine, Mayo Clinic, Rochester, MN, USA
*Corresponding author; P.U.: [email protected], [email protected]
Funding: None
ED
Conflict of interest statement for all authors: We do not have any financial or nonfinancial potential conflicts of interest.
AC
CE
PT
Authors’ contributions: All authors had access to the data and a role in writing the manuscript.
ACCEPTED MANUSCRIPT ECG changes and prognosis of Takotsubo cardiomyopathy
SC
RI P
T
We read the article “Stimulant-related Takotsubo cardiomyopathy” by Butterfield et al. [1] in the previous issue of the American Journal of Emergency medicine with great interest. The authors described a very interesting case of Takotsubo cardiomyopathy (TC) associated with cocaine abuse. The patient did have a remarkable electrocardiogram (ECG) changes and was successfully treated with conservative management. We would like to emphasize two important issues related to this case presentation. First, although the majority of patients with TC have ECG changes at presentation, as seen in the this case, up to 30% of patients could have a completely normal ECG [2, 3]. Thus, a normal ECG does not always rule out the diagnosis of TC. Second, TC is not always a benign condition and sometimes an aggressive intervention is required as a recent systematic review had demonstrated an in-hospital mortality of up to 3% [2].
AC
CE
PT
ED
MA NU
Reference 1. Butterfield M, Riguzzi C, Frenkel O, Nagdev A. Stimulant-related Takotsubo cardiomyopathy. Am J Emerg Med. 2014 Sep 6 [Epub ahead of print] 2. Ahmed S, Ungprasert P, Ratanapo S, Hussain T, Riesenfeld EP. Clinical characteristics of takotsubo cardiomyopathy in north america. N Am J Med Sci. 2013 Feb;5(2):77-81. 3. Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, et al. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1,109 Patients. Am J Med. 2015 Feb 3 [Epub ahead of print]
S0735-6757(15)00083-2 doi: 10.1016/j.ajem.2015.02.021 YAJEM 54808
To appear in:
American Journal of Emergency Medicine
Received date: Accepted date:
10 February 2015 11 February 2015
Please cite this article as: Ungprasert Patompong, Srivali Narat, ECG changes and prognosis of Takotsubo cardiomyopathy, American Journal of Emergency Medicine (2015), doi: 10.1016/j.ajem.2015.02.021
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Title page Title: ECG changes and prognosis of Takotsubo cardiomyopathy
RI P
Authors: *Patompong Ungprasert, MD1, Narat Srivali, MD2
T
Article type: Letter to editor
1 Division of rheumatology, Mayo Clinic, Rochester, MN, USA
MA NU
SC
2 Division of pulmonology and critical care medicine, Mayo Clinic, Rochester, MN, USA
*Corresponding author; P.U.: [email protected], [email protected]
Funding: None
ED
Conflict of interest statement for all authors: We do not have any financial or nonfinancial potential conflicts of interest.
AC
CE
PT
Authors’ contributions: All authors had access to the data and a role in writing the manuscript.
ACCEPTED MANUSCRIPT ECG changes and prognosis of Takotsubo cardiomyopathy
SC
RI P
T
We read the article “Stimulant-related Takotsubo cardiomyopathy” by Butterfield et al. [1] in the previous issue of the American Journal of Emergency medicine with great interest. The authors described a very interesting case of Takotsubo cardiomyopathy (TC) associated with cocaine abuse. The patient did have a remarkable electrocardiogram (ECG) changes and was successfully treated with conservative management. We would like to emphasize two important issues related to this case presentation. First, although the majority of patients with TC have ECG changes at presentation, as seen in the this case, up to 30% of patients could have a completely normal ECG [2, 3]. Thus, a normal ECG does not always rule out the diagnosis of TC. Second, TC is not always a benign condition and sometimes an aggressive intervention is required as a recent systematic review had demonstrated an in-hospital mortality of up to 3% [2].
AC
CE
PT
ED
MA NU
Reference 1. Butterfield M, Riguzzi C, Frenkel O, Nagdev A. Stimulant-related Takotsubo cardiomyopathy. Am J Emerg Med. 2014 Sep 6 [Epub ahead of print] 2. Ahmed S, Ungprasert P, Ratanapo S, Hussain T, Riesenfeld EP. Clinical characteristics of takotsubo cardiomyopathy in north america. N Am J Med Sci. 2013 Feb;5(2):77-81. 3. Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, et al. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1,109 Patients. Am J Med. 2015 Feb 3 [Epub ahead of print]
