Am J Cancer Res 2016;6(6):1431-1440 www.ajcr.us /ISSN:2156-6976/ajcr0029416
Original Article Elevated ASCL2 expression is associated with metastasis of osteosarcoma and predicts poor prognosis of the patients Ming-Han Liu1, You-Hong Cui2,3, Qiao-Nan Guo4, Yue Zhou1 Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; 3Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China; 4Department of Pathology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China 1 2
Received April 17, 2016; Accepted April 18, 2016; Epub June 1, 2016; Published June 15, 2016 Abstract: Achaetescute-like 2 (ASCL2), a basic helix-loop-helix (bHLH) transcription factor, plays an important role in the determination of neuronal precursors in the central and peripheral nervous system and involves in tumor progression. However, the role of ASCL2 expression in the osteosarcoma prognosis has not been elaborated. This study aimed to evaluate ASCL2 expression level in osteosarcoma and assess its prognostic value for patients. ASCL2 protein expression was detected by immunohistochemistry (IHC) in 73 cases of osteosarcoma. KaplanMeier analysis and Cox regression analysis were performed to evaluate the prognostic significance of ASCL2. Immunohistochemistry analysis showed that the overall survival and metastasis-free survival of patients with positive ASCL2 expression were significantly shorter than patients with negative expression (both P
Original Article Elevated ASCL2 expression is associated with metastasis of osteosarcoma and predicts poor prognosis of the patients Ming-Han Liu1, You-Hong Cui2,3, Qiao-Nan Guo4, Yue Zhou1 Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; 3Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China; 4Department of Pathology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China 1 2
Received April 17, 2016; Accepted April 18, 2016; Epub June 1, 2016; Published June 15, 2016 Abstract: Achaetescute-like 2 (ASCL2), a basic helix-loop-helix (bHLH) transcription factor, plays an important role in the determination of neuronal precursors in the central and peripheral nervous system and involves in tumor progression. However, the role of ASCL2 expression in the osteosarcoma prognosis has not been elaborated. This study aimed to evaluate ASCL2 expression level in osteosarcoma and assess its prognostic value for patients. ASCL2 protein expression was detected by immunohistochemistry (IHC) in 73 cases of osteosarcoma. KaplanMeier analysis and Cox regression analysis were performed to evaluate the prognostic significance of ASCL2. Immunohistochemistry analysis showed that the overall survival and metastasis-free survival of patients with positive ASCL2 expression were significantly shorter than patients with negative expression (both P
