Emerging role of long non-coding RNAs in autoimmune diseases Guo-Cui Wu, Hai-Feng Pan, Rui-Xue Leng, De-Guang Wang, XiangPei Li, Xiao-Mei Li, Dong-Qing Ye PII: DOI: Reference:
S1568-9972(15)00112-3 doi: 10.1016/j.autrev.2015.05.004 AUTREV 1718
To appear in:
Autoimmunity Reviews
Received date: Accepted date:
7 April 2015 7 May 2015
Please cite this article as: Wu Guo-Cui, Pan Hai-Feng, Leng Rui-Xue, Wang De-Guang, Li Xiang-Pei, Li Xiao-Mei, Ye Dong-Qing, Emerging role of long non-coding RNAs in autoimmune diseases, Autoimmunity Reviews (2015), doi: 10.1016/j.autrev.2015.05.004
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Emerging role of long non-coding RNAs in autoimmune diseases Guo-Cui Wu1,2, Hai-Feng Pan1,2, Rui-Xue Leng1,2, De-Guang Wang3, Xiang-Pei Li4, Xiao-Mei Li4,
IP
T
Dong-Qing Ye1,2* 1
SC R
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China;
2
Anhui provincial laboratory of population health & major disease screening and diagnosis, Anhui
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678
MA
3
NU
Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China;
Furong Road, Hefei, 230601, Anhui, China.
Department of Rheumatology and Immunology, Anhui Provincial Hospital, Affiliated to Anhui
D
4
TE
Medical University, 17 Lujiang Road, Hefei 230001, Anhui, China.
CE P
Running Head: LncRNAs in autoimmune diseases * Correspondence: Dong-Qing Ye, M.D, Department of Epidemiology and Biostatistics, School
AC
of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. E-mail: [email protected], [email protected]. Tel: +86 551 65167726; Fax: +86 551 65161171
ACCEPTED MANUSCRIPT Abstract Long non-coding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of
IP
T
non-coding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation
SC R
of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune
NU
responses, immune cell development, and differential expression of lncRNAs in autoimmune
MA
diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis,
TE
D
polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).
AC
CE P
Keywords: lncRNA; non-coding RNA; immune function; autoimmunity; autoimmune disease
ACCEPTED MANUSCRIPT 1. Introduction Over the past decades, pervasive studies mainly focused on the protein-coding genes.
IP
T
Nevertheless, the genome-wide transcriptome analyses including recent studies by the ENCODE
SC R
(Encyclopedia of DNA Elements) Consortium, have revealed that mammalian genomes are pervasively, but not indiscriminately, transcribed, giving rise to a wide variety of coding and noncoding RNA (ncRNA) transcripts [1, 2]. Previously, the noncoding transcripts has always been
NU
regarded as junk DNA and transcript noises for some time [3], however, recent studies suggests
MA
that these ncRNAs are also implicated in the physiological processes that maintain cellular and tissue homeostasis [4-6]. NcRNAs are loosely grouped into two major classes according to the
D
transcript size: small ncRNAs (
S1568-9972(15)00112-3 doi: 10.1016/j.autrev.2015.05.004 AUTREV 1718
To appear in:
Autoimmunity Reviews
Received date: Accepted date:
7 April 2015 7 May 2015
Please cite this article as: Wu Guo-Cui, Pan Hai-Feng, Leng Rui-Xue, Wang De-Guang, Li Xiang-Pei, Li Xiao-Mei, Ye Dong-Qing, Emerging role of long non-coding RNAs in autoimmune diseases, Autoimmunity Reviews (2015), doi: 10.1016/j.autrev.2015.05.004
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Emerging role of long non-coding RNAs in autoimmune diseases Guo-Cui Wu1,2, Hai-Feng Pan1,2, Rui-Xue Leng1,2, De-Guang Wang3, Xiang-Pei Li4, Xiao-Mei Li4,
IP
T
Dong-Qing Ye1,2* 1
SC R
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China;
2
Anhui provincial laboratory of population health & major disease screening and diagnosis, Anhui
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678
MA
3
NU
Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China;
Furong Road, Hefei, 230601, Anhui, China.
Department of Rheumatology and Immunology, Anhui Provincial Hospital, Affiliated to Anhui
D
4
TE
Medical University, 17 Lujiang Road, Hefei 230001, Anhui, China.
CE P
Running Head: LncRNAs in autoimmune diseases * Correspondence: Dong-Qing Ye, M.D, Department of Epidemiology and Biostatistics, School
AC
of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. E-mail: [email protected], [email protected]. Tel: +86 551 65167726; Fax: +86 551 65161171
ACCEPTED MANUSCRIPT Abstract Long non-coding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of
IP
T
non-coding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation
SC R
of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune
NU
responses, immune cell development, and differential expression of lncRNAs in autoimmune
MA
diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis,
TE
D
polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).
AC
CE P
Keywords: lncRNA; non-coding RNA; immune function; autoimmunity; autoimmune disease
ACCEPTED MANUSCRIPT 1. Introduction Over the past decades, pervasive studies mainly focused on the protein-coding genes.
IP
T
Nevertheless, the genome-wide transcriptome analyses including recent studies by the ENCODE
SC R
(Encyclopedia of DNA Elements) Consortium, have revealed that mammalian genomes are pervasively, but not indiscriminately, transcribed, giving rise to a wide variety of coding and noncoding RNA (ncRNA) transcripts [1, 2]. Previously, the noncoding transcripts has always been
NU
regarded as junk DNA and transcript noises for some time [3], however, recent studies suggests
MA
that these ncRNAs are also implicated in the physiological processes that maintain cellular and tissue homeostasis [4-6]. NcRNAs are loosely grouped into two major classes according to the
D
transcript size: small ncRNAs (
