Endobronchial ultrasound echoic image of pulmonary hamartoma Shigehisa Kajikawa, Naoyuki Imai, Kouji Takashima, Kazuyoshi Imaizumi & Yoshinori Hasegawa Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
Keywords EBUS-TBNA, hamartoma, ultrasound image. Correspondence Shigehisa Kajikawa, Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466–8550 Nagoya, Japan. E-mail: [email protected] Received: 22 January 2014; Revised: 18 March 2014; Accepted: 24 March 2014
Abstract A 62-year-old man with an indicated chest radiographic abnormality was referred to our hospital for more thorough examinations. Endobronchial ultrasoundguided transbronchial needle aspiration was performed because of a mass at the left hilum. Endobronchial ultrasound images showed scattered high-density spots in a low echoic and mosaic density. The pathological findings revealed pulmonary hamartoma. Subsequently, the mass was resected and comparison of ultrasound findings and pathological findings indicated that the scattered high echoic spots appeared to reflect cartilaginous tissues and bronchial epithelium inside the tumor.
Respirology Case Reports 2014; 2(2): 85–86 doi: 10.1002/rcr2.57
Introduction Hamartoma is a benign tumor of the lung and is mostly located peripherally. It is diagnosed by transbronchial lung biopsy, transbronchial fine needle aspiration, or surgery. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a useful procedure for the pathological examinations of not only mediastinal lymph nodes but also of hilar lesion of the lung [1]. Here, we report a case of pulmonary hamartoma at the hilum that was diagnosed with EBUS-TBNA, showing a unique ultrasound (US) finding. In addition, we assessed the correlation between macropathological sectional view of the resisted tumor and EBUS findings.
Case Report A 62-year-old man was referred to our hospital for further investigations of a chest radiographic abnormality. A chest X-ray revealed a left hilar mass. The patient had been smoking one and a half packs of cigarettes per day for 42 years. Chest computed tomography imaging revealed an oval mass at the left hilum with a size of 37 mm in diameter and a smooth surface (Fig. 1a). No calcifications or fatty tissue density was
detected inside the mass shadow. Enhanced chest computed tomography imaging showed no contrast within the mass. To obtain tissue samples for pathological diagnosis, we performed EBUS-TBNA (UC-260FW, Olympus, Tokyo, Japan) under conscious sedation with midazolam and local anesthesia with lidocaine. The endobronchial appearance directly disproved mass and mucosal lesions, and only the left lower bronchus was slightly compressed. EBUS images showed scattered high-density spots in a low echoic and mosaic density (Fig. 1b). A Doppler evaluation not used during US demonstrated the cause of the visible solid findings. Further, we punctured the lesion four times with a 22G needle without rapid onsite evaluation. The biopsied specimens were hard and showed typical findings of a pulmonary hamartoma upon pathological examination. Dysplasia or malignancy could not be observed (Fig. 1c). These findings suggested the diagnosis of a pulmonary hamartoma and video-assisted thoracic surgery was performed to resect the tumor 2 months after the EBUS-TBNA (Fig. 1d). The patient has been followed up without any indication of recurrence. Using the resected specimen, we compared US findings with pathological findings. As shown in Figure 1b,d, scattered high echoic spots appeared to reflect cartilaginous tissues and bronchial epithelium inside the tumor.
© 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
85
Ultrasound image of pulmonary hamartoma
S. Kajikawa et al.
Figure 1. (a) Computed tomography finding revealed that a low-dense mass lesion with a smooth surface located concordant to #11 L lymph node. (b) The echoic feature of the mass showed heterogeneous mosaic pattern with scattered high-density spots in the low echoic area. (c) The biopsied specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration. The microphotograph showing myxomatous fibroblasts covered cartilaginous tissue and bronchial epithelium. (d) Section of the resected mass. The area in the square corresponds to the echoic finding, and pathological finding. The high density spots indicate the cartilage part, and low-density area show fatty tissue and connective tissue.
Discussion
Disclosure Statements
A pulmonary hamartoma is mostly located in the peripheral lung and is rarely found in a hilar lesion or an endobronchial lesion [2]. A previous study reported only one out of 221 cases in which pulmonary hamartomas was located in the mediastinum [3]. Previously, Hata et al. reported a case of a hilar hamartoma that was diagnosed by EBUS-TBNA [4] with US findings similar to our findings. In this report, we compared the echoic features with the macropathological findings of the resected tumor, which revealed that scattered high echoic spots appeared to reflect cartilaginous tissues and bronchial epithelium inside the tumor. In general, heterogeneous findings on US images are likely to be malignant lesions [5]. We believed that these were caused by complex internal components of the mass. It is a rare for a pulmonary tumor to involve cartilaginous tissues, and there are few diseases with EBUS findings similar to those for this case. To the best of our knowledge, this is the first report of direct comparisons between EBUS findings and pathological findings of a hamartoma. In conclusion, we encountered the distinctive echoic findings of a pulmonary hamartoma by EBUS and compared these with the pathological findings of a resected tumor.
No conflict of interest declared.
86
Appropriate written informed consent was obtained for publication of this case report and accompanying images.
References 1. Nakajima T, Yasufuku K, Fujiwara T, et al. 2008. Endobronchial ultrasound-guided transbronchial needle aspiration for diagnosis of intrapulmonary lesions. J. Thorac. Oncol. 3(9):985–988. 2. Lien YC, Hsu HS, Li WY, et al. 2004. Pulmonary hamartoma. J. Chin. Med. Assoc. 67:21–26. 3. Gjevre JA, Myers JL, and Prakash UB. 1996. Pulmonary hamartomas. Mayo Clin. Proc. 71:14–20. 4. Hata Y, Isobe K, Sasamoto S, et al. 2010. Pulmonary hamartoma diagnosed by convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Intern. Med. 49(12):1171–1173. 5. Fujiwara T, Yasufuku K, Nakajima T, et al. 2010. The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer. Chest 138:641–647.
© 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology
Keywords EBUS-TBNA, hamartoma, ultrasound image. Correspondence Shigehisa Kajikawa, Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466–8550 Nagoya, Japan. E-mail: [email protected] Received: 22 January 2014; Revised: 18 March 2014; Accepted: 24 March 2014
Abstract A 62-year-old man with an indicated chest radiographic abnormality was referred to our hospital for more thorough examinations. Endobronchial ultrasoundguided transbronchial needle aspiration was performed because of a mass at the left hilum. Endobronchial ultrasound images showed scattered high-density spots in a low echoic and mosaic density. The pathological findings revealed pulmonary hamartoma. Subsequently, the mass was resected and comparison of ultrasound findings and pathological findings indicated that the scattered high echoic spots appeared to reflect cartilaginous tissues and bronchial epithelium inside the tumor.
Respirology Case Reports 2014; 2(2): 85–86 doi: 10.1002/rcr2.57
Introduction Hamartoma is a benign tumor of the lung and is mostly located peripherally. It is diagnosed by transbronchial lung biopsy, transbronchial fine needle aspiration, or surgery. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a useful procedure for the pathological examinations of not only mediastinal lymph nodes but also of hilar lesion of the lung [1]. Here, we report a case of pulmonary hamartoma at the hilum that was diagnosed with EBUS-TBNA, showing a unique ultrasound (US) finding. In addition, we assessed the correlation between macropathological sectional view of the resisted tumor and EBUS findings.
Case Report A 62-year-old man was referred to our hospital for further investigations of a chest radiographic abnormality. A chest X-ray revealed a left hilar mass. The patient had been smoking one and a half packs of cigarettes per day for 42 years. Chest computed tomography imaging revealed an oval mass at the left hilum with a size of 37 mm in diameter and a smooth surface (Fig. 1a). No calcifications or fatty tissue density was
detected inside the mass shadow. Enhanced chest computed tomography imaging showed no contrast within the mass. To obtain tissue samples for pathological diagnosis, we performed EBUS-TBNA (UC-260FW, Olympus, Tokyo, Japan) under conscious sedation with midazolam and local anesthesia with lidocaine. The endobronchial appearance directly disproved mass and mucosal lesions, and only the left lower bronchus was slightly compressed. EBUS images showed scattered high-density spots in a low echoic and mosaic density (Fig. 1b). A Doppler evaluation not used during US demonstrated the cause of the visible solid findings. Further, we punctured the lesion four times with a 22G needle without rapid onsite evaluation. The biopsied specimens were hard and showed typical findings of a pulmonary hamartoma upon pathological examination. Dysplasia or malignancy could not be observed (Fig. 1c). These findings suggested the diagnosis of a pulmonary hamartoma and video-assisted thoracic surgery was performed to resect the tumor 2 months after the EBUS-TBNA (Fig. 1d). The patient has been followed up without any indication of recurrence. Using the resected specimen, we compared US findings with pathological findings. As shown in Figure 1b,d, scattered high echoic spots appeared to reflect cartilaginous tissues and bronchial epithelium inside the tumor.
© 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
85
Ultrasound image of pulmonary hamartoma
S. Kajikawa et al.
Figure 1. (a) Computed tomography finding revealed that a low-dense mass lesion with a smooth surface located concordant to #11 L lymph node. (b) The echoic feature of the mass showed heterogeneous mosaic pattern with scattered high-density spots in the low echoic area. (c) The biopsied specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration. The microphotograph showing myxomatous fibroblasts covered cartilaginous tissue and bronchial epithelium. (d) Section of the resected mass. The area in the square corresponds to the echoic finding, and pathological finding. The high density spots indicate the cartilage part, and low-density area show fatty tissue and connective tissue.
Discussion
Disclosure Statements
A pulmonary hamartoma is mostly located in the peripheral lung and is rarely found in a hilar lesion or an endobronchial lesion [2]. A previous study reported only one out of 221 cases in which pulmonary hamartomas was located in the mediastinum [3]. Previously, Hata et al. reported a case of a hilar hamartoma that was diagnosed by EBUS-TBNA [4] with US findings similar to our findings. In this report, we compared the echoic features with the macropathological findings of the resected tumor, which revealed that scattered high echoic spots appeared to reflect cartilaginous tissues and bronchial epithelium inside the tumor. In general, heterogeneous findings on US images are likely to be malignant lesions [5]. We believed that these were caused by complex internal components of the mass. It is a rare for a pulmonary tumor to involve cartilaginous tissues, and there are few diseases with EBUS findings similar to those for this case. To the best of our knowledge, this is the first report of direct comparisons between EBUS findings and pathological findings of a hamartoma. In conclusion, we encountered the distinctive echoic findings of a pulmonary hamartoma by EBUS and compared these with the pathological findings of a resected tumor.
No conflict of interest declared.
86
Appropriate written informed consent was obtained for publication of this case report and accompanying images.
References 1. Nakajima T, Yasufuku K, Fujiwara T, et al. 2008. Endobronchial ultrasound-guided transbronchial needle aspiration for diagnosis of intrapulmonary lesions. J. Thorac. Oncol. 3(9):985–988. 2. Lien YC, Hsu HS, Li WY, et al. 2004. Pulmonary hamartoma. J. Chin. Med. Assoc. 67:21–26. 3. Gjevre JA, Myers JL, and Prakash UB. 1996. Pulmonary hamartomas. Mayo Clin. Proc. 71:14–20. 4. Hata Y, Isobe K, Sasamoto S, et al. 2010. Pulmonary hamartoma diagnosed by convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Intern. Med. 49(12):1171–1173. 5. Fujiwara T, Yasufuku K, Nakajima T, et al. 2010. The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer. Chest 138:641–647.
© 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology
