Journal o f Neurocytology 8, 9 5 - 1 1 5
(1979)
Endplates after esterase inactivation in vivo" correlation between esterase concentration, functional response and fine structure MIRIAM HUSUAN
M. SALPETER, HEDWIG KASPRZAK, FENG and H E L E N FERTUCK
Section of Neuro biology and Behavior, and Department of Applied Physics, 146 Clark Hall, Cornell University, Ithaca, New York 14853, U.S.A. Received 13 J u n e 1978; revised 10 O c t o b e r 1978; a c c e p t e d 16 O c t o b e r 1978
Summary Mouse sternomastoid muscles were incubated with diisopropylfluorophosphate (DFP) in vivo, and the time course of recovery was studied using histochemistry, EM autoradiography and physiology. We found that: (1) the ability of the muscle to sustain tetanus in response to nerve stimulation is eliminated when the esterases at the neuromuscular junctions are saturated with DFP. This ability is regained partially when
(1979)
Endplates after esterase inactivation in vivo" correlation between esterase concentration, functional response and fine structure MIRIAM HUSUAN
M. SALPETER, HEDWIG KASPRZAK, FENG and H E L E N FERTUCK
Section of Neuro biology and Behavior, and Department of Applied Physics, 146 Clark Hall, Cornell University, Ithaca, New York 14853, U.S.A. Received 13 J u n e 1978; revised 10 O c t o b e r 1978; a c c e p t e d 16 O c t o b e r 1978
Summary Mouse sternomastoid muscles were incubated with diisopropylfluorophosphate (DFP) in vivo, and the time course of recovery was studied using histochemistry, EM autoradiography and physiology. We found that: (1) the ability of the muscle to sustain tetanus in response to nerve stimulation is eliminated when the esterases at the neuromuscular junctions are saturated with DFP. This ability is regained partially when
