Iranian Journal of Basic Medical Sciences ijbms.mums.ac.ir

Endurance training induces fiber type-specific revascularization in hindlimb skeletal muscles of rats with chronic heart failure Kamal Ranjbar 1, Malihe Ardakanizade 2, Farzad Nazem 3* Department of Physical Education and Sport Science, Bandar Abbas branch, Islamic Azad University, Bandar Abbas, Iran School of Humanities, Department of Sport Science, Damghan University, Damghan, Iran 3 Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu-Ali Sina University, Hamedan, Iran 1 2

ARTICLE INFO

Article type:

Original article

Article history:

Received: Jul 23, 2015 Accepted: Oct 20, 2016 Keywords: Chronic heart failure Endurance training Fast and slow twitch muscles Revascularization

ABSTRACT Objective(s): Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. Materials and Methods: Four weeks after surgeries (left anterior descending (LAD) artery occlusion), chronic heart failure rats were divided into 3 groups: Sham (Sham, n=10); Sedentary (Sed, n=10); Exercise training (Ex, n=10). Ex group rats were subjected to endurance training in the form of treadmill running with moderate intensity for 10 weeks. Results: Exercise training significantly increased capillary density and capillary to fiber ratio (P