Journal of the American Society of Hypertension 9(4S) (2015) e63–e72

EPIDEMIOLOGY/SPECIAL POPULATIONS P-95 Hypokalemic metabolic alkalosis and hypertension in white and black patients Arif Asif, Daniel Sedhom, Krishnakumar Hongalgi, Roy Matthew, Shamim Haqqie. Albany Medical Center, Albany, NY, United States Hypertension presenting with metabolic alkalosis with hypokalemia is not uncommon. In this analysis, we present the management of such a scenario in white and black patients. Six patients (white¼4 [1 females, 2 males, age¼24-62]; blacks¼2 [1male, 1 female, age¼32, 40]) with hypokalemia (2.9-3.3 mEq/L), metabolic alkalosis (28-32 mm Eq/L) and hypertension (155-180/90-105 mmHg) were seen in hypertension clinic. All had a BMI of >32 and metabolic syndrome. None had clinical evidence of sleep apnea. All had been on adequate dosage of at least three BP meds (calcium channel blocker, ACE-I/ARB, metoprolol/carvedilol). All had a negative Doppler ultrasound for renal artery stenosis. Their serum aldosterone to renin ratio was 15-18 (normal¼less than 20). Urinary aldosterone in the six patients ranged from 10-12 ng/l (reference abnormal¼>14 ng/dl). Because of normal aldosterone to renin ration, CT scan was not obtained in these patients. Nonetheless, considering obesity and aldosterone production by adipocytes (high normal urinary aldosterone), treatment with spironolactone/eplerenone was initiated with normalization of blood pressure in 3/4 whites (

Enhancement of protoporphyrin IX performance in aqueous solutions for photodynamic therapy.

Molecular modification of protoporphyrin IX (PpIX) was conducted to improve its water solubility and therapeutic performance for photodynamic therapy...
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