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malaria infections in travellers from West Africa
Epidemic alert:
SIR,-Frequent reference has been made to the rise in incidence of Plasmodium falciparum malaria in non-immune travellers.1,2 This has been attributed to the increased number of travellers to Africa exposed to infection, and to greater risk of breakthrough as a result of the spread of chloroquine-resistant P falciparum malaria. Chloroquine-resistant malaria was first reported in East Africa in 1978, but has only lately been observed in West Africa.’ The dilemma of chemoprophylaxis against P falciparum infectionswhether to prescribe effective but potentially toxic antimalarial drugs (eg, pyrimethamine/sulphadoxine, pyrimethamine/dapsone) or safe but less effective antimalarials (eg, chloroquine and proguanil)-has thus largely been confined to travellers visiting Effects of 60 mg
sinorphan (oral) on plasma ANF and enkephalinase activity in seven patients with severe congestive heart failure. Data as mean
(SEM).’p
malaria infections in travellers from West Africa
Epidemic alert:
SIR,-Frequent reference has been made to the rise in incidence of Plasmodium falciparum malaria in non-immune travellers.1,2 This has been attributed to the increased number of travellers to Africa exposed to infection, and to greater risk of breakthrough as a result of the spread of chloroquine-resistant P falciparum malaria. Chloroquine-resistant malaria was first reported in East Africa in 1978, but has only lately been observed in West Africa.’ The dilemma of chemoprophylaxis against P falciparum infectionswhether to prescribe effective but potentially toxic antimalarial drugs (eg, pyrimethamine/sulphadoxine, pyrimethamine/dapsone) or safe but less effective antimalarials (eg, chloroquine and proguanil)-has thus largely been confined to travellers visiting Effects of 60 mg
sinorphan (oral) on plasma ANF and enkephalinase activity in seven patients with severe congestive heart failure. Data as mean
(SEM).’p
