Vol.

177,

No.

June

28,

1991

3, 1991

BIOCHEMICAL

AND

BIOPHYSICAL

RESEARCH

COMMUNICATIONS Pages

991-997

ERYTHROPOIETIN INCREASES CYTOSOLIC FREE CALCIUM CONCENTRATION AND THROMBIN INDUCED CHANGES IN CYTOSOLIC FREE CALCIUM IN PLATELETS FROM SPONTANEOUSLY HYPERTENSIVE RATS Martin

Tepell,

Med.

Univ .-Poliklinik,

Received

May 7, 1991

Hubert

Wischniowski,

University

and Walter

of Muenster,

Zidek

Muenster,

Germany

SUMMARY: Using furacytosolic free calcium concentrations were measured in intact washed platelets from 9 spontaneously hypertensive rats (SHR) and from 9 age-matched nonnotensive platelets cytosolic free Wistar-Kyoto rats (WKY). In resting calcium concentration was significantly higher in SHR than in WKY (171.8 f. 64.4 nM vs 93.1 + 59.0 nM, p