www.impactjournals.com/oncotarget/
Oncotarget, 2017, Vol. 8, (No. 26), pp: 43397-43405 Clinical Research Paper
Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma Yu-Shang Yang1, Wei-Peng Hu1, Peng-Zhi Ni1, Wen-Ping Wang1, Yong Yuan1 and Long-Qi Chen1 1
Department of Thoracic Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China
Correspondence to: Long-Qi Chen, email: [email protected] Keywords: esophageal cancer, outcomes, endoscopy, esophagectomy Received: September 20, 2016
Accepted: January 10, 2017
Published: January 19, 2017
Copyright: Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT Background. Predictive value of preoperative endoscopic characteristic of esophageal tumor has not been fully evaluated. The aim of this study is to investigate the impact of esophageal luminal stenosis on survival for patients with resectable esophageal squamous cell carcinoma (ESCC). Methods. The clinicopathologic characteristics of 623 ESCC patients who underwent curative resection as the primary treatment between January 2005 and April 2009 were retrospectively reviewed. The esophageal luminal stenosis measured by endoscopy was defined as a uniform measurement preoperatively. The impact of esophageal luminal stenosis on patients’ overall survival (OS) and relation with other clinicopathological features were assessed. A Cox regression model was used to identify prognostic factors. Results. The results showed that OS significantly decreased in patients with manifest stenotic tumor compared with patients without luminal obstruction (P
Oncotarget, 2017, Vol. 8, (No. 26), pp: 43397-43405 Clinical Research Paper
Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma Yu-Shang Yang1, Wei-Peng Hu1, Peng-Zhi Ni1, Wen-Ping Wang1, Yong Yuan1 and Long-Qi Chen1 1
Department of Thoracic Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China
Correspondence to: Long-Qi Chen, email: [email protected] Keywords: esophageal cancer, outcomes, endoscopy, esophagectomy Received: September 20, 2016
Accepted: January 10, 2017
Published: January 19, 2017
Copyright: Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT Background. Predictive value of preoperative endoscopic characteristic of esophageal tumor has not been fully evaluated. The aim of this study is to investigate the impact of esophageal luminal stenosis on survival for patients with resectable esophageal squamous cell carcinoma (ESCC). Methods. The clinicopathologic characteristics of 623 ESCC patients who underwent curative resection as the primary treatment between January 2005 and April 2009 were retrospectively reviewed. The esophageal luminal stenosis measured by endoscopy was defined as a uniform measurement preoperatively. The impact of esophageal luminal stenosis on patients’ overall survival (OS) and relation with other clinicopathological features were assessed. A Cox regression model was used to identify prognostic factors. Results. The results showed that OS significantly decreased in patients with manifest stenotic tumor compared with patients without luminal obstruction (P
