+Model DIABET-609; No. of Pages 7
ARTICLE IN PRESS Available online at
ScienceDirect www.sciencedirect.com Diabetes & Metabolism xxx (2014) xxx–xxx
Original article
Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women K.K. Ryckman a,∗, E. Rillamas-Sun b, C.N. Spracklen a, R.B. Wallace a,j, L. Garcia c, F.A. Tylavsky d, B.V. Howard e , S. Liu f , Y. Song f , E.S. LeBlanc g , M.V. White h , N.I. Parikh i , J.G. Robinson a,j a
Department of Epidemiology, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, IA 52242, United States b Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, United States c Department of Public Health Sciences, University of California at Davis, Med Sci 1C, Davis, CA, United States d Department of Preventive Medicine, University of Tennessee Health Science Center, 600 Jefferson Avenue, Memphis, TN 38105, United States e Medstar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Research, 6525 Belcrest Road #700, Hyattsville, MD, United States f Department of Epidemiology, University of California, Box 951740, 27-138 CHS, Los Angeles, CA 90095, United States g Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227, United States h Department of Family, Community and Rural Health, The Commonwealth Medical College, Medical Sciences Building, Room 1013, 525 Pine Street, Scranton, PA 18509, United States i John A. Burns School of Medicine and Cardiovascular Division, University of Hawaii, The Queens Medical Center, 1301 Punchbowl Street, Honolulu, HI 96813, United States j Department of Internal Medicine, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, United States Received 24 February 2014; received in revised form 19 March 2014; accepted 22 March 2014
Abstract Aim. – The objective of this study is to examine the relationship between self-reported birth weight and the adult occurrence of type 2 diabetes mellitus in a large multi-ethnic population of women. Methods. – Baseline data from the Women’s Health Initiative Observational Study [n = 75,993] was used to examine the association between participant birth weight category and prevalent type 2 diabetes mellitus. Models were adjusted for age, ethnicity, body mass index and other pertinent risk factors. Sub-analyses were performed stratifying by ethnicity. Results. – There was a strong inverse association between birth weight and type 2 diabetes mellitus with a birth weight of
ARTICLE IN PRESS Available online at
ScienceDirect www.sciencedirect.com Diabetes & Metabolism xxx (2014) xxx–xxx
Original article
Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women K.K. Ryckman a,∗, E. Rillamas-Sun b, C.N. Spracklen a, R.B. Wallace a,j, L. Garcia c, F.A. Tylavsky d, B.V. Howard e , S. Liu f , Y. Song f , E.S. LeBlanc g , M.V. White h , N.I. Parikh i , J.G. Robinson a,j a
Department of Epidemiology, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, IA 52242, United States b Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, United States c Department of Public Health Sciences, University of California at Davis, Med Sci 1C, Davis, CA, United States d Department of Preventive Medicine, University of Tennessee Health Science Center, 600 Jefferson Avenue, Memphis, TN 38105, United States e Medstar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Research, 6525 Belcrest Road #700, Hyattsville, MD, United States f Department of Epidemiology, University of California, Box 951740, 27-138 CHS, Los Angeles, CA 90095, United States g Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227, United States h Department of Family, Community and Rural Health, The Commonwealth Medical College, Medical Sciences Building, Room 1013, 525 Pine Street, Scranton, PA 18509, United States i John A. Burns School of Medicine and Cardiovascular Division, University of Hawaii, The Queens Medical Center, 1301 Punchbowl Street, Honolulu, HI 96813, United States j Department of Internal Medicine, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, United States Received 24 February 2014; received in revised form 19 March 2014; accepted 22 March 2014
Abstract Aim. – The objective of this study is to examine the relationship between self-reported birth weight and the adult occurrence of type 2 diabetes mellitus in a large multi-ethnic population of women. Methods. – Baseline data from the Women’s Health Initiative Observational Study [n = 75,993] was used to examine the association between participant birth weight category and prevalent type 2 diabetes mellitus. Models were adjusted for age, ethnicity, body mass index and other pertinent risk factors. Sub-analyses were performed stratifying by ethnicity. Results. – There was a strong inverse association between birth weight and type 2 diabetes mellitus with a birth weight of
