Nyawanda et al. BMC Infectious Diseases (2016) 16:218 DOI 10.1186/s12879-016-1532-0
RESEARCH ARTICLE
Open Access
Evaluation of case definitions to detect respiratory syncytial virus infection in hospitalized children below 5 years in Rural Western Kenya, 2009–2013 Bryan O. Nyawanda1*, Joshua A. Mott2,3, Henry N. Njuguna2, Lilian Mayieka1, Sammy Khagayi1, Reuben Onkoba1, Caroline Makokha1, Nancy A. Otieno1, Godfrey M. Bigogo1, Mark A. Katz3, Daniel R. Feikin3 and Jennifer R. Verani2,3
Abstract Background: In order to better understand respiratory syncytial virus (RSV) epidemiology and burden in tropical Africa, optimal case definitions for detection of RSV cases need to be identified. Methods: We used data collected between September 2009 - August 2013 from children aged 75 %. Of the standard respiratory case definitions, SARI had the highest sensitivity [83 %, 95 % CI (79–86)] whereas IMCI severe pneumonia had the highest specificity [91 %, 95 % CI (90–92)]. The alternative case definition (cough or difficulty breathing plus hypoxia, in-drawing, or wheeze) had a sensitivity of [55 %, 95 % CI (50–59)] and a specificity of [60 %, 95 % CI (59–62)]. The PPV for all case definitions and individual signs/symptoms ranged from 11 to 20 % while the negative predictive values were >87 %. When we stratified by age
RESEARCH ARTICLE
Open Access
Evaluation of case definitions to detect respiratory syncytial virus infection in hospitalized children below 5 years in Rural Western Kenya, 2009–2013 Bryan O. Nyawanda1*, Joshua A. Mott2,3, Henry N. Njuguna2, Lilian Mayieka1, Sammy Khagayi1, Reuben Onkoba1, Caroline Makokha1, Nancy A. Otieno1, Godfrey M. Bigogo1, Mark A. Katz3, Daniel R. Feikin3 and Jennifer R. Verani2,3
Abstract Background: In order to better understand respiratory syncytial virus (RSV) epidemiology and burden in tropical Africa, optimal case definitions for detection of RSV cases need to be identified. Methods: We used data collected between September 2009 - August 2013 from children aged 75 %. Of the standard respiratory case definitions, SARI had the highest sensitivity [83 %, 95 % CI (79–86)] whereas IMCI severe pneumonia had the highest specificity [91 %, 95 % CI (90–92)]. The alternative case definition (cough or difficulty breathing plus hypoxia, in-drawing, or wheeze) had a sensitivity of [55 %, 95 % CI (50–59)] and a specificity of [60 %, 95 % CI (59–62)]. The PPV for all case definitions and individual signs/symptoms ranged from 11 to 20 % while the negative predictive values were >87 %. When we stratified by age
