CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 3943-3950 DOI: 10.12659/MSM.898160
Evaluation of Early Atherosclerosis Markers in Patients with Inflammatory Bowel Disease
Received: 2015.02.22 Accepted: 2016.03.03 Published: 2016.10.24
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
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Corresponding Author: Source of support:
Background:
Material/Methods:
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Yusuf Üstün Serta Kilincalp Şahin Çoban Yusuf Coşkun İlhami Yüksel Aydan Ongun İrfan Soykan Mehmet Bektaş Murat Törüner Hülya Çetinkaya Necati Örmeci
1 Department of Gastroenterology, Dıskapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey 2 Department of Cardiology, Ankara University, School of Medicine, Ankara, Turkey 3 Department of Gastroenterology, Ankara University, School of Medicine, Ankara, Turkey
Yusuf Üstün, e-mail: [email protected] Departmental sources
The aim of this study was to investigate relationships between early atherosclerosis and inflammatory bowel disease (IBD) using laboratory, functional, and morphological markers of atherosclerosis. In the present prospective single-center study, 96 patients with IBD (58 patients with ulcerative colitis and 36 patients with Crohn’s disease) and 65 healthy control subjects were included. The demographic data of each patient and control subject were recorded. The patients with IBD and healthy controls were compared in terms of the carotid intima-media thickness (CIMT), the values of flow-mediated dilatation (FMD) and nitroglycerinemediated dilatation (NMD), and the levels of von Willebrand factor antigen (VWF-Ag), D-dimer, and lipoprotein (a). There were no significant differences between the IBD patients and controls in terms of age, sex, BMI, systolic and diastolic BPs, serum levels of total cholesterol, low-density lipoprotein, or triglycerides. IBD patients had significantly higher levels of VWF-Ag (156.6±58.9 vs. 104.2±43.3, P
Evaluation of Early Atherosclerosis Markers in Patients with Inflammatory Bowel Disease
Received: 2015.02.22 Accepted: 2016.03.03 Published: 2016.10.24
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
ABC 1 E 1 AB 1 BC 1 C 1 BD 2 DF 3
F 3
DE 3
AD 3
AE 3
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Yusuf Üstün Serta Kilincalp Şahin Çoban Yusuf Coşkun İlhami Yüksel Aydan Ongun İrfan Soykan Mehmet Bektaş Murat Törüner Hülya Çetinkaya Necati Örmeci
1 Department of Gastroenterology, Dıskapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey 2 Department of Cardiology, Ankara University, School of Medicine, Ankara, Turkey 3 Department of Gastroenterology, Ankara University, School of Medicine, Ankara, Turkey
Yusuf Üstün, e-mail: [email protected] Departmental sources
The aim of this study was to investigate relationships between early atherosclerosis and inflammatory bowel disease (IBD) using laboratory, functional, and morphological markers of atherosclerosis. In the present prospective single-center study, 96 patients with IBD (58 patients with ulcerative colitis and 36 patients with Crohn’s disease) and 65 healthy control subjects were included. The demographic data of each patient and control subject were recorded. The patients with IBD and healthy controls were compared in terms of the carotid intima-media thickness (CIMT), the values of flow-mediated dilatation (FMD) and nitroglycerinemediated dilatation (NMD), and the levels of von Willebrand factor antigen (VWF-Ag), D-dimer, and lipoprotein (a). There were no significant differences between the IBD patients and controls in terms of age, sex, BMI, systolic and diastolic BPs, serum levels of total cholesterol, low-density lipoprotein, or triglycerides. IBD patients had significantly higher levels of VWF-Ag (156.6±58.9 vs. 104.2±43.3, P
