XML Template (2015) [17.2.2015–7:19pm] //blrnas3.glyph.com/cenpro/ApplicationFiles/Journals/SAGE/3B2/LUPJ/Vol00000/150008/APPFile/SG-LUPJ150008.3d
(LUP)
[1–10] [PREPRINTER stage]
Lupus (2015) 0,
1–10
http://lup.sagepub.com
PAPER
Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies A Barutcu1, F Aksu2, F Ozcelik3, CAE Barutcu4, GE Umit4, ON Pamuk5 and A Altun6 1
Department of Cardiology, Faculty of Medicine, C¸anakkale Onsekiz Mart University, C¸anakkale, Turkey; 2Istanbul Medeniyet University , Cardiology Goztepe Training and Research Hospital, Istanbul, Turkey; 3Department of Cardiology, Faculty of Medicine, Trakya University, Edirne, Turkey; 4Department of Internal Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey; 5Deprtmet of Rheumatology, Faculty of Meicine,Trakya University, Edirne, Turkey; and 6Department of Cardiology, Faculty of Medicine, Baskent University, Istanbul Hospital, Istanbul, Turkey
The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n ¼ 50) and control group (n ¼ 30). They were categorized into four subgroups: anticardiolipin antibodies (aCL) (þ) (n ¼ 14) and aCL () (n ¼ 36); systemic lupus erythematosus disease activity index (SLEDAI) 6 (n ¼ 15) and SLEDAI < 6 (n ¼ 35); disease period 5 years (n ¼ 21) and disease period < 5 years (n ¼ 29); major organ involvement (þ) (n ¼ 19), major organ involvement () (n ¼ 31). The ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E0 ) for the study group was found to be higher than the control (p < 0.01). Systolic septal motion velocity (Ssm) was lower in the study group compared with the control (p < 0.01). Left atrium (LA) dimension was greater in the study group than the control (p < 0.01). Ssm was found to be lower in the aCL (þ) patients compared with the control and aCL () groups (p < 0.01, p < 0.05, respectively). LA dimension was greater in the aCL (þ) and () groups compared with the control, (p < 0.01, p < 0.05, respectively) and aCL groups compared with each other (p < 0.05). The E/E0 ratio for the aCL (þ) and () groups was found to be greater than the control (p < 0.05). In the study, both the Ssm and the late diastolic septal velocity (sA0 ) was found to be lower in the SLEDAI 6 group compared with SLEDAI
(LUP)
[1–10] [PREPRINTER stage]
Lupus (2015) 0,
1–10
http://lup.sagepub.com
PAPER
Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies A Barutcu1, F Aksu2, F Ozcelik3, CAE Barutcu4, GE Umit4, ON Pamuk5 and A Altun6 1
Department of Cardiology, Faculty of Medicine, C¸anakkale Onsekiz Mart University, C¸anakkale, Turkey; 2Istanbul Medeniyet University , Cardiology Goztepe Training and Research Hospital, Istanbul, Turkey; 3Department of Cardiology, Faculty of Medicine, Trakya University, Edirne, Turkey; 4Department of Internal Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey; 5Deprtmet of Rheumatology, Faculty of Meicine,Trakya University, Edirne, Turkey; and 6Department of Cardiology, Faculty of Medicine, Baskent University, Istanbul Hospital, Istanbul, Turkey
The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n ¼ 50) and control group (n ¼ 30). They were categorized into four subgroups: anticardiolipin antibodies (aCL) (þ) (n ¼ 14) and aCL () (n ¼ 36); systemic lupus erythematosus disease activity index (SLEDAI) 6 (n ¼ 15) and SLEDAI < 6 (n ¼ 35); disease period 5 years (n ¼ 21) and disease period < 5 years (n ¼ 29); major organ involvement (þ) (n ¼ 19), major organ involvement () (n ¼ 31). The ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E0 ) for the study group was found to be higher than the control (p < 0.01). Systolic septal motion velocity (Ssm) was lower in the study group compared with the control (p < 0.01). Left atrium (LA) dimension was greater in the study group than the control (p < 0.01). Ssm was found to be lower in the aCL (þ) patients compared with the control and aCL () groups (p < 0.01, p < 0.05, respectively). LA dimension was greater in the aCL (þ) and () groups compared with the control, (p < 0.01, p < 0.05, respectively) and aCL groups compared with each other (p < 0.05). The E/E0 ratio for the aCL (þ) and () groups was found to be greater than the control (p < 0.05). In the study, both the Ssm and the late diastolic septal velocity (sA0 ) was found to be lower in the SLEDAI 6 group compared with SLEDAI
