Clinical Neurophysiology 126 (2015) 275–283
Contents lists available at ScienceDirect
Clinical Neurophysiology journal homepage: www.elsevier.com/locate/clinph
Evaluation of somatosensory cortical processing in extremely preterm infants at term with MEG and EEG Päivi Nevalainen a,b,⇑, Petri Rahkonen c, Elina Pihko d, Aulikki Lano e, Sampsa Vanhatalo b, Sture Andersson c, Taina Autti f, Leena Valanne f, Marjo Metsäranta c, Leena Lauronen a,b a
BioMag Laboratory, Hospital District of Helsinki and Uusimaa, HUS Medical Imaging Center, Helsinki University Central Hospital (HUCH), Helsinki, Finland Department of Clinical Neurophysiology, Children’s Hospital, HUS Medical Imaging Center, HUCH, University of Helsinki, Helsinki, Finland Department of Pediatrics, Children’s Hospital, HUCH, University of Helsinki, Helsinki, Finland d Brain Research Unit, O.V. Lounasmaa Laboratory, Aalto University School of Science, Espoo, Finland e Department of Child Neurology, Children’s Hospital, HUCH, University of Helsinki, Helsinki, Finland f Department of Radiology, HUS Medical Imaging Center, HUCH, Helsinki, Finland b c
See Editorial, pages 223–224
a r t i c l e
i n f o
Article history: Accepted 13 May 2014 Available online 25 June 2014 Keywords: Magnetoencephalography (MEG) Somatosensory evoked potentials (SEPs) Somatosensory evoked fields (SEFs) Secondary somatosensory cortex (SII) Preterm infant
h i g h l i g h t s Secondary somatosensory cortex (SII) responses complement neonatal neurological evaluation in
predicting neurodevelopmental outcome in extremely preterm infants. SII responses can be measured with MEG as well as with the routinely available bedside EEG-SEP
recordings. Use of sensory responses as a part of routine EEG studies holds promise to significantly expand early
neurophysiological evaluation of neonates after adversities.
a b s t r a c t Objective: Prior studies on extremely preterm infants have reported long-term prognostic value of absent secondary somatosensory cortex (SII) responses in magnetoencephalography (MEG) at term. The present work (i) further examines the potential added value of SII responses in neonatal neurological evaluation of preterm infants, and (ii) tests whether SII responses are detectable in routine neonatal electroencephalogram complemented with median nerve stimulation (EEG-SEP). Methods: Altogether 29 infants born
Contents lists available at ScienceDirect
Clinical Neurophysiology journal homepage: www.elsevier.com/locate/clinph
Evaluation of somatosensory cortical processing in extremely preterm infants at term with MEG and EEG Päivi Nevalainen a,b,⇑, Petri Rahkonen c, Elina Pihko d, Aulikki Lano e, Sampsa Vanhatalo b, Sture Andersson c, Taina Autti f, Leena Valanne f, Marjo Metsäranta c, Leena Lauronen a,b a
BioMag Laboratory, Hospital District of Helsinki and Uusimaa, HUS Medical Imaging Center, Helsinki University Central Hospital (HUCH), Helsinki, Finland Department of Clinical Neurophysiology, Children’s Hospital, HUS Medical Imaging Center, HUCH, University of Helsinki, Helsinki, Finland Department of Pediatrics, Children’s Hospital, HUCH, University of Helsinki, Helsinki, Finland d Brain Research Unit, O.V. Lounasmaa Laboratory, Aalto University School of Science, Espoo, Finland e Department of Child Neurology, Children’s Hospital, HUCH, University of Helsinki, Helsinki, Finland f Department of Radiology, HUS Medical Imaging Center, HUCH, Helsinki, Finland b c
See Editorial, pages 223–224
a r t i c l e
i n f o
Article history: Accepted 13 May 2014 Available online 25 June 2014 Keywords: Magnetoencephalography (MEG) Somatosensory evoked potentials (SEPs) Somatosensory evoked fields (SEFs) Secondary somatosensory cortex (SII) Preterm infant
h i g h l i g h t s Secondary somatosensory cortex (SII) responses complement neonatal neurological evaluation in
predicting neurodevelopmental outcome in extremely preterm infants. SII responses can be measured with MEG as well as with the routinely available bedside EEG-SEP
recordings. Use of sensory responses as a part of routine EEG studies holds promise to significantly expand early
neurophysiological evaluation of neonates after adversities.
a b s t r a c t Objective: Prior studies on extremely preterm infants have reported long-term prognostic value of absent secondary somatosensory cortex (SII) responses in magnetoencephalography (MEG) at term. The present work (i) further examines the potential added value of SII responses in neonatal neurological evaluation of preterm infants, and (ii) tests whether SII responses are detectable in routine neonatal electroencephalogram complemented with median nerve stimulation (EEG-SEP). Methods: Altogether 29 infants born
