International Journal of Pharmaceutics 461 (2014) 469–477

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Evaluation of the hyperbranched polymer Hybrane H1500 for production of matricial controlled-release particles by hot-melt extrusion ˜ Elena Ravina-Eirín, Blanca Sánchez-Rodríguez, Jose Luis Gómez-Amoza, Ramón Martínez-Pacheco ∗ Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Spain

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Article history: Received 14 October 2013 Received in revised form 11 December 2013 Accepted 14 December 2013 Available online 22 December 2013 Keywords: Hot melt extrusion Hybrane H1500 Controlled release particles Acetaminophen Caffeine Hyperbranched polymer

a b s t r a c t Extrudates of the hyperbranched polymer Hybrane H1500 prepared by hot melt extrusion, with five particle sizes (from 1.5 mm) and grinding

%D5 min ± SD

DE24 h ± SD

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