DOI 10.1515/jpem-2013-0401      J Pediatr Endocr Met 2014; 27(7-8): 709–715

Jarmila Vojtková*, Peter Ďurdík, Zuzana Michnová, Tomáš Turčan and Miriam Čiljaková

Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy Abstract: The aim of the study was to determine if cardiovascular autonomic neuropathy (CAN) is associated with changed concentration of exhaled carbon monoxide (eCO) in adolescents with type 1 diabetes (T1D). A total of 46 T1D patients and 25 healthy controls (15–19 years) were enrolled. The parameters eCO and carboxyhemoglobin (HbCO) were established using a MICRO-4 Smokerlyser. CAN was examined by standard cardiovascular tests. Adolescents with T1D did not significantly differ in eCO compared to healthy subjects. eCO and HbCO were significantly lower in CAN-positive subjects (n = 19) (1.36 ± 1.65 ppm vs. 3.09 ± 2.31, p = 0.01 and 0.58 ± 0.49% vs. 1.04 ± 0.44, p  0.05    0.05   0.05  > 0.05  > 0.05

CAN, cardiovascular autonomic neuropathy; HbA1c, glycosylated hemoglobin; BMI, body mass index; eCO, exhaled carbon monoxide; HbCO, carboxyhemoglobin. p-Value in italic font, statistically significant result.

Table 4 Multivariate logistic regression of measured parameters. Risk factor

 

OR 

95 CI 

p-Value

Age, years   Diabetes duration, years  Diabetes onset, years   Fasting glucose, mmol/L  HbA1c, %   BMI, kg/m2   Creatinine, mmol/L   Bilirubin, mmol/L   Uric acid, μmol/L   eCO, ppm   HbCO, %  

1.252  0.965  1.092  0.939  1.049  0.952  0.991  1.026  1.008  1.824  10.989 

0.864–1.815  0.844–1.104  0.952–1.253  0.823–1.072  0.838–1.314  0.785–1.156  0.944–1.041  0.923–1.137  0.996–1.021  1.052–3.165  1.548–76.923 

 > 0.05  > 0.05  > 0.05  > 0.05  > 0.05  > 0.05  > 0.05  > 0.05  > 0.05