J Cancer Res Clin Oncol DOI 10.1007/s00432-014-1854-5
ORIGINAL ARTICLE - CANCER RESEARCH
Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer Yan‑Long Liu · Xu Gao · Yang Jiang · Gan Zhang · Zi‑Cheng Sun · Bin‑Bin Cui · Yan‑Mei Yang
Received: 9 May 2014 / Accepted: 8 October 2014 © Springer-Verlag Berlin Heidelberg 2014
Abstract Background and objectives Enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 homolog (SUZ12), the key component of polycomb repressive complex 2, are of great importance in human cancer pathogenesis. This study was designed to investigate the clinical and prognostic significances of EZH2, EED and SUZ12 in colorectal cancer (CRC) patients. Methods The expression of EZH2, EED and SUZ12 mRNA was evaluated in 82 primary CRC and paired noncancerous mucosa samples by qRT-PCR.
Yan-Long Liu, Xu Gao and Yang Jiang have contributed equally to the work. Y.-L. Liu · G. Zhang · B.-B. Cui (*) Department of Colorectal Surgery, The Affiliated Tumor Hospital, Harbin Medical University, No. 150, Haping Rd, Nangang District, Harbin 150081, Heilongjiang, China e-mail: [email protected] X. Gao Department of Biochemistry and Molecular Biology, Basic Medical Sciences, Harbin Medical University, Harbin, Heilonjiang, China Y. Jiang Department of Pathology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, Heilonjiang, China Z.-C. Sun Department of General Surgery, The First People’s Hospital, Mudanjiang City, China Y.-M. Yang (*) Cancer Research Institute, Harbin Medical University, No. 6, Baojian Rd, Nangang District, Harbin 150081, Heilongjiang, China e-mail: [email protected]
Results We found that overall EZH2, EED and SUZ12 mRNA expression in the CRC tissues was significantly increased than in the non-cancerous tissue (p
ORIGINAL ARTICLE - CANCER RESEARCH
Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer Yan‑Long Liu · Xu Gao · Yang Jiang · Gan Zhang · Zi‑Cheng Sun · Bin‑Bin Cui · Yan‑Mei Yang
Received: 9 May 2014 / Accepted: 8 October 2014 © Springer-Verlag Berlin Heidelberg 2014
Abstract Background and objectives Enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 homolog (SUZ12), the key component of polycomb repressive complex 2, are of great importance in human cancer pathogenesis. This study was designed to investigate the clinical and prognostic significances of EZH2, EED and SUZ12 in colorectal cancer (CRC) patients. Methods The expression of EZH2, EED and SUZ12 mRNA was evaluated in 82 primary CRC and paired noncancerous mucosa samples by qRT-PCR.
Yan-Long Liu, Xu Gao and Yang Jiang have contributed equally to the work. Y.-L. Liu · G. Zhang · B.-B. Cui (*) Department of Colorectal Surgery, The Affiliated Tumor Hospital, Harbin Medical University, No. 150, Haping Rd, Nangang District, Harbin 150081, Heilongjiang, China e-mail: [email protected] X. Gao Department of Biochemistry and Molecular Biology, Basic Medical Sciences, Harbin Medical University, Harbin, Heilonjiang, China Y. Jiang Department of Pathology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, Heilonjiang, China Z.-C. Sun Department of General Surgery, The First People’s Hospital, Mudanjiang City, China Y.-M. Yang (*) Cancer Research Institute, Harbin Medical University, No. 6, Baojian Rd, Nangang District, Harbin 150081, Heilongjiang, China e-mail: [email protected]
Results We found that overall EZH2, EED and SUZ12 mRNA expression in the CRC tissues was significantly increased than in the non-cancerous tissue (p
