ONCOLOGY LETTERS 14: 411-415, 2017
Expression of autophagy‑associated proteins in papillary thyroid carcinoma MEILIU YANG1, LU BAI1, WU YU2, XUELING SUN3, GANG XU4, RUHUA GUAN5, YING YANG3, MINGYUE QIU3, YAZHONG ZHANG3, JINLI TIAN3 and HUI FANG3 1
Department of Medical Experimental Center, North China University of Science and Technology, Tangshan, Hebei 063000; 2Department of Surgery, Qianan Yejituo Hospital, Qianan, Hebei 064400; Departments of 3Endocrinology and 4Burn, Tangshan Worker Hospital, Tangshan, Hebei 063000; 5 Department of Endocrinology, Hebei Yanda Hospital, San He, Hebei 065201, P.R. China Received June 18, 2015; Accepted March 21, 2017 DOI: 10.3892/ol.2017.6101 Abstract. The present study was designed to assess the protein expression of the autophagy‑associated genes, Beclin‑1 and microtubule‑associated protein 1 light chain 3 (LC3)‑II, as well as the association with clinicopathological features in papillary thyroid carcinoma (PTC). A total of 50 subjects were recruited, including 50 human PTC samples and paired adjacent noncancerous tissue samples. The protein expression of Beclin‑1 and LC3‑II was analyzed using immunohistochemistry and western blotting. Beclin‑1 and LC3‑II expression in PTC tissues significantly reduced compared with normal tissues (P
Expression of autophagy‑associated proteins in papillary thyroid carcinoma MEILIU YANG1, LU BAI1, WU YU2, XUELING SUN3, GANG XU4, RUHUA GUAN5, YING YANG3, MINGYUE QIU3, YAZHONG ZHANG3, JINLI TIAN3 and HUI FANG3 1
Department of Medical Experimental Center, North China University of Science and Technology, Tangshan, Hebei 063000; 2Department of Surgery, Qianan Yejituo Hospital, Qianan, Hebei 064400; Departments of 3Endocrinology and 4Burn, Tangshan Worker Hospital, Tangshan, Hebei 063000; 5 Department of Endocrinology, Hebei Yanda Hospital, San He, Hebei 065201, P.R. China Received June 18, 2015; Accepted March 21, 2017 DOI: 10.3892/ol.2017.6101 Abstract. The present study was designed to assess the protein expression of the autophagy‑associated genes, Beclin‑1 and microtubule‑associated protein 1 light chain 3 (LC3)‑II, as well as the association with clinicopathological features in papillary thyroid carcinoma (PTC). A total of 50 subjects were recruited, including 50 human PTC samples and paired adjacent noncancerous tissue samples. The protein expression of Beclin‑1 and LC3‑II was analyzed using immunohistochemistry and western blotting. Beclin‑1 and LC3‑II expression in PTC tissues significantly reduced compared with normal tissues (P
