British lourndo! Haernatology. 1992. 81, 499-502
Extended cytogenetic follow-up of patients with myelodysplastic syndrome (MDS) A. D. W H I T E , D. J. C U L L I G A N T. , G. HOY A N D A . JACOBS* Department ofHaematoZogy. University of Wales College of Medicine, Cardif
Received 11 November 1991; acceptedfor publication 30 March 1992
Summary. The prognostic significance of clonal karyotype status in myelodysplasticsyndrome (MDS)is assessed after an extended follow-up period of 5 years. There are three prognostic sub-groups according to the presence of a normal karyotype, single abnormalities or multiple abnormalities at the time of referral. However, there is no correlation between the size of the abnormal clone and prognosis. Karyotype status has independent prognostic significance in ‘high risk’ MDS so that patients with a refractory anaemia with excess of blasts (RAEB)/RAEB in transformation (RAEB-t) and a normal karyotype survive significantly longer than those with an abnormal karyotype (P
Extended cytogenetic follow-up of patients with myelodysplastic syndrome (MDS) A. D. W H I T E , D. J. C U L L I G A N T. , G. HOY A N D A . JACOBS* Department ofHaematoZogy. University of Wales College of Medicine, Cardif
Received 11 November 1991; acceptedfor publication 30 March 1992
Summary. The prognostic significance of clonal karyotype status in myelodysplasticsyndrome (MDS)is assessed after an extended follow-up period of 5 years. There are three prognostic sub-groups according to the presence of a normal karyotype, single abnormalities or multiple abnormalities at the time of referral. However, there is no correlation between the size of the abnormal clone and prognosis. Karyotype status has independent prognostic significance in ‘high risk’ MDS so that patients with a refractory anaemia with excess of blasts (RAEB)/RAEB in transformation (RAEB-t) and a normal karyotype survive significantly longer than those with an abnormal karyotype (P
