World J Gastroenterol 2016 June 14; 22(22): 5228-5236 ISSN 1007-9327 (print) ISSN 2219-2840 (online)
Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.3748/wjg.v22.i22.5228
© 2016 Baishideng Publishing Group Inc. All rights reserved.
ORIGINAL ARTICLE Case Control Study
Factors affecting occurrence of gastric varioliform lesions: A case-control study Tian-Hui Zou, Ru-Hua Zheng, Qin-Yan Gao, Xuan Kong, Xiao-Yu Chen, Zhi-Zheng Ge, Ying-Xuan Chen, Xiao-Ping Zou, Jing-Yuan Fang the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/
Tian-Hui Zou, Qin-Yan Gao, Xuan Kong, Xiao-Yu Chen, ZhiZheng Ge, Ying-Xuan Chen, Jing-Yuan Fang, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China Ru-Hua Zheng, Xiao-Ping Zou, Division of Gastroenterology and Hepatology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Correspondence to: Jing-Yuan Fang, PhD, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, No. 145 Shandong Zhonglu, Shanghai 200001, China. [email protected] Telephone: +86-21-63200874 Fax: +86-21-63266027
Author contributions: Zou TH performed telephone interviews of most participants and wrote the manuscript; Zheng RH performed part of the telephone interviews; Gao QY and Kong X provided analytical tools; Chen XY offered the pathological data; Ge ZZ offered the endoscopic data; Chen YX served as scientific advisors; Fang JY designed the study and edited the manuscript; all authors approved the final version of the manuscript.
Received: January 18, 2016 Peer-review started: January 19, 2016 First decision: March 7, 2016 Revised: March 16, 2016 Accepted: March 30, 2016 Article in press: March 30, 2016 Published online: June 14, 2016
Supported by National Natural Science Foundation of China, No. 31371420 (to FJY); the National Key Technology R and D Program, No. 2014BAI09B05 (to CYX); and the National Natural Science Foundation of China, No. 81402347 (to KX).
Abstract AIM: To investigate the factors influencing the occurrence of gastric varioliform lesions (GVLs) and their possible link with gastric cancer.
Institutional review board statement: The study was approved by Shanghai Jiao Tong University School of Medicine. Informed consent statement: All patients gave informed consent.
METHODS: A 1:1 matched case-control study was performed to retrospectively analyze data from 1638 chronic gastritis patients who had undergone gastroscopy at one of two Chinese hospitals between 2009 and 2014. Patients with GVLs (cases) were compared to those without such lesions (controls). Endoscopic and pathological findings were recorded, along with interview information on Helicobacter pylori (H. pylori ) infection, medical, drug and family histories, lifestyle and eating habits. The association between each factor and the occurrence of GVLs was estimated, and then multivariate conditional logistic regression was used to evaluate the independent factors.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. Data sharing statement: Statistical code and dataset available from the corresponding author at [email protected]. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and
WJG|www.wjgnet.com
RESULTS: The frequency and severity of glandular
5228
June 14, 2016|Volume 22|Issue 22|
Zou TH et al . Factors affecting varioliform gastritis
atrophy, intestinal metaplasia (IM) and low-grade intraepithelial neoplasia were significantly increased in the GVL group (P < 0.01). Overall analysis showed that H. pylori infection [3.051 (2.157, 4.317), P
Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.3748/wjg.v22.i22.5228
© 2016 Baishideng Publishing Group Inc. All rights reserved.
ORIGINAL ARTICLE Case Control Study
Factors affecting occurrence of gastric varioliform lesions: A case-control study Tian-Hui Zou, Ru-Hua Zheng, Qin-Yan Gao, Xuan Kong, Xiao-Yu Chen, Zhi-Zheng Ge, Ying-Xuan Chen, Xiao-Ping Zou, Jing-Yuan Fang the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/
Tian-Hui Zou, Qin-Yan Gao, Xuan Kong, Xiao-Yu Chen, ZhiZheng Ge, Ying-Xuan Chen, Jing-Yuan Fang, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China Ru-Hua Zheng, Xiao-Ping Zou, Division of Gastroenterology and Hepatology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Correspondence to: Jing-Yuan Fang, PhD, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, No. 145 Shandong Zhonglu, Shanghai 200001, China. [email protected] Telephone: +86-21-63200874 Fax: +86-21-63266027
Author contributions: Zou TH performed telephone interviews of most participants and wrote the manuscript; Zheng RH performed part of the telephone interviews; Gao QY and Kong X provided analytical tools; Chen XY offered the pathological data; Ge ZZ offered the endoscopic data; Chen YX served as scientific advisors; Fang JY designed the study and edited the manuscript; all authors approved the final version of the manuscript.
Received: January 18, 2016 Peer-review started: January 19, 2016 First decision: March 7, 2016 Revised: March 16, 2016 Accepted: March 30, 2016 Article in press: March 30, 2016 Published online: June 14, 2016
Supported by National Natural Science Foundation of China, No. 31371420 (to FJY); the National Key Technology R and D Program, No. 2014BAI09B05 (to CYX); and the National Natural Science Foundation of China, No. 81402347 (to KX).
Abstract AIM: To investigate the factors influencing the occurrence of gastric varioliform lesions (GVLs) and their possible link with gastric cancer.
Institutional review board statement: The study was approved by Shanghai Jiao Tong University School of Medicine. Informed consent statement: All patients gave informed consent.
METHODS: A 1:1 matched case-control study was performed to retrospectively analyze data from 1638 chronic gastritis patients who had undergone gastroscopy at one of two Chinese hospitals between 2009 and 2014. Patients with GVLs (cases) were compared to those without such lesions (controls). Endoscopic and pathological findings were recorded, along with interview information on Helicobacter pylori (H. pylori ) infection, medical, drug and family histories, lifestyle and eating habits. The association between each factor and the occurrence of GVLs was estimated, and then multivariate conditional logistic regression was used to evaluate the independent factors.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. Data sharing statement: Statistical code and dataset available from the corresponding author at [email protected]. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and
WJG|www.wjgnet.com
RESULTS: The frequency and severity of glandular
5228
June 14, 2016|Volume 22|Issue 22|
Zou TH et al . Factors affecting varioliform gastritis
atrophy, intestinal metaplasia (IM) and low-grade intraepithelial neoplasia were significantly increased in the GVL group (P < 0.01). Overall analysis showed that H. pylori infection [3.051 (2.157, 4.317), P
