Glaucoma
Factors Affecting Plastic Lamina Cribrosa Displacement in Glaucoma Patients Kyoung In Jung, Younhea Jung, Kyoung Tae Park, and Chan Kee Park Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence: Chan Kee Park, Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137701, Korea; [email protected]. Submitted: January 15, 2014 Accepted: October 20, 2014 Citation: Jung KI, Jung Y, Park KT, Park CK. Factors affecting plastic lamina cribrosa displacement in glaucoma patients. Invest Ophthalmol Vis Sci. 2014;55:7709–7715. DOI:10.1167/ iovs.14-13957
PURPOSE. To investigate factors associated with irreversible components of anterior lamina cribrosa (LC) depth in glaucoma patients. METHODS. A total of 141 glaucoma patients and 51 healthy control subjects were enrolled. The optic nerve head (ONH) was imaged using the enhanced depth imaging (EDI) modes of Spectralis optical coherence tomography (OCT). The depth of the LC was measured at the midhorizontal, superior, and inferior midperipheral regions of the ONH of each eye. Analyzed factors associated LC depth included age, axial length, intraocular pressure (IOP), disc size, central corneal thickness, average retinal nerve fiber layer (RNFL) thickness, and mean deviation (MD). RESULTS. In glaucoma patients, the LC was more deeply located compared with the control group at the midhorizontal and superior and inferior midperipheral B-scans (All P < 0.001). Age, initial IOP, and treated IOP was correlated with mean LC depth (All P < 0.001), and those correlations remained after adjusting for MD and RNFL thickness (All P < 0.001). In multivariate analysis, younger age, high untreated IOP, and thinner RNFL thickness was significantly associated with a deeper LC (P ¼ 0.015, 0.05). Table 1 lists the demographics of the study population. No significant differences appeared in terms of age, sex, axial length, or disc size between the healthy and
TABLE 1. Clinical Characteristics of Subjects in the Study
Age, y Sex, male/female Initial IOP, mm Hg Treated IOP, mm Hg Axial length, mm CCT, lm Disc size, mm2 RNFL thickness, lm MD, dB PSD, dB LC depth, lm Inferior Midhorizontal Superior Mean Maximum
Control, n ¼ 51
Glaucoma, n ¼ 141
P Value*
55.9 6 11.6 19/32 14.26 6 2.74 14.26 6 2.74 23.83 6 1.06 536.81 6 27.02 2.07 6 0.40 94.10 6 6.48 0.39 6 1.14 1.56 6 0.33
59.3 6 13.0 57/84 21.37 6 6.13 13.86 6 3.10 23.93 6 1.18 533.13 6 31.67 2.18 6 0.45 68.56 6 12.66 9.00 6 7.65 7.80 6 4.40
0.122 0.740
Factors Affecting Plastic Lamina Cribrosa Displacement in Glaucoma Patients Kyoung In Jung, Younhea Jung, Kyoung Tae Park, and Chan Kee Park Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence: Chan Kee Park, Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137701, Korea; [email protected]. Submitted: January 15, 2014 Accepted: October 20, 2014 Citation: Jung KI, Jung Y, Park KT, Park CK. Factors affecting plastic lamina cribrosa displacement in glaucoma patients. Invest Ophthalmol Vis Sci. 2014;55:7709–7715. DOI:10.1167/ iovs.14-13957
PURPOSE. To investigate factors associated with irreversible components of anterior lamina cribrosa (LC) depth in glaucoma patients. METHODS. A total of 141 glaucoma patients and 51 healthy control subjects were enrolled. The optic nerve head (ONH) was imaged using the enhanced depth imaging (EDI) modes of Spectralis optical coherence tomography (OCT). The depth of the LC was measured at the midhorizontal, superior, and inferior midperipheral regions of the ONH of each eye. Analyzed factors associated LC depth included age, axial length, intraocular pressure (IOP), disc size, central corneal thickness, average retinal nerve fiber layer (RNFL) thickness, and mean deviation (MD). RESULTS. In glaucoma patients, the LC was more deeply located compared with the control group at the midhorizontal and superior and inferior midperipheral B-scans (All P < 0.001). Age, initial IOP, and treated IOP was correlated with mean LC depth (All P < 0.001), and those correlations remained after adjusting for MD and RNFL thickness (All P < 0.001). In multivariate analysis, younger age, high untreated IOP, and thinner RNFL thickness was significantly associated with a deeper LC (P ¼ 0.015, 0.05). Table 1 lists the demographics of the study population. No significant differences appeared in terms of age, sex, axial length, or disc size between the healthy and
TABLE 1. Clinical Characteristics of Subjects in the Study
Age, y Sex, male/female Initial IOP, mm Hg Treated IOP, mm Hg Axial length, mm CCT, lm Disc size, mm2 RNFL thickness, lm MD, dB PSD, dB LC depth, lm Inferior Midhorizontal Superior Mean Maximum
Control, n ¼ 51
Glaucoma, n ¼ 141
P Value*
55.9 6 11.6 19/32 14.26 6 2.74 14.26 6 2.74 23.83 6 1.06 536.81 6 27.02 2.07 6 0.40 94.10 6 6.48 0.39 6 1.14 1.56 6 0.33
59.3 6 13.0 57/84 21.37 6 6.13 13.86 6 3.10 23.93 6 1.18 533.13 6 31.67 2.18 6 0.45 68.56 6 12.66 9.00 6 7.65 7.80 6 4.40
0.122 0.740
