635874
research-article2016
MSJ0010.1177/1352458516635874Multiple Sclerosis JournalM Cavallari, M Palotai
MULTIPLE SCLEROSIS MSJ JOURNAL
Original Research Paper
Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients Michele Cavallari, Miklos Palotai, Bonnie I Glanz, Svetlana Egorova, Juan Carlos Prieto, Brian C Healy, Tanuja Chitnis and Charles RG Guttmann
Multiple Sclerosis Journal 1–9 DOI: 10.1177/ 1352458516635874 © The Author(s), 2016. Reprints and permissions: http://www.sagepub.co.uk/ journalsPermissions.nav
Abstract Background: It is unclear whether fatigue is a consequence or a predictive trait of disease worsening. Objective: To investigate the predictive value of fatigue toward conversion to confirmed moderate– severe disability in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: We retrospectively selected from the Comprehensive Longitudinal Investigations in MS at the Brigham and Women’s Hospital (CLIMB) study cohort RRMS patients who converted to confirmed (⩾2 years) Expanded Disability Status Scale (EDSS) score ⩾3 within a follow-up period ⩾3 years. We contrasted the Modified Fatigue Impact Scale (MFIS) score of 33 converters, obtained at least 1 year before conversion to EDSS ⩾3, with that of 33 non-converter RRMS patients matched for baseline characteristics. Results: Total MFIS score was higher in converter versus non-converter MS patients (median 37 vs 13; p
research-article2016
MSJ0010.1177/1352458516635874Multiple Sclerosis JournalM Cavallari, M Palotai
MULTIPLE SCLEROSIS MSJ JOURNAL
Original Research Paper
Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients Michele Cavallari, Miklos Palotai, Bonnie I Glanz, Svetlana Egorova, Juan Carlos Prieto, Brian C Healy, Tanuja Chitnis and Charles RG Guttmann
Multiple Sclerosis Journal 1–9 DOI: 10.1177/ 1352458516635874 © The Author(s), 2016. Reprints and permissions: http://www.sagepub.co.uk/ journalsPermissions.nav
Abstract Background: It is unclear whether fatigue is a consequence or a predictive trait of disease worsening. Objective: To investigate the predictive value of fatigue toward conversion to confirmed moderate– severe disability in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: We retrospectively selected from the Comprehensive Longitudinal Investigations in MS at the Brigham and Women’s Hospital (CLIMB) study cohort RRMS patients who converted to confirmed (⩾2 years) Expanded Disability Status Scale (EDSS) score ⩾3 within a follow-up period ⩾3 years. We contrasted the Modified Fatigue Impact Scale (MFIS) score of 33 converters, obtained at least 1 year before conversion to EDSS ⩾3, with that of 33 non-converter RRMS patients matched for baseline characteristics. Results: Total MFIS score was higher in converter versus non-converter MS patients (median 37 vs 13; p
