PRENATAL DIAGNOSIS,VOL.
11 , 4 4 3 4 0 (199 1)
FIIIST-TRIMESTER MATERNAL SERUM ALPHAFETOPROTEIN A N D CHORIONIC GONADOTROPIN IN ANEUPLOID PREGNANCIES .4NTHONY JOHNSON*?, F. SUSAN COWCHOCK*, MARILYN DARBY$t, RONALD WAPNER*t AND LAIRD G. JACKSON* 'Division of Medical Generics and ?Division of Maternal-Fetal Medicine, Jefferson Medical College, Philadelphia, P A , U.S.A.
SUMMARY First-trimester maternal serum alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) levels were measured in samples from 29 women with cytogenetically abnormal pregnancies and 145 women with cytogeneticallynormal pregnancies matched for gestational age, race, and sample storage time. All patients had a risk of fetal aneuploidy greater than or equal to that of a mother 35 years of age. AFP was significantly lower in samples from pregnancies affected with trisomy 21 (0.67 MoM;p 0.05). Assays were completed without knowledge of the cytogenetic diagnoses. The levels of AFP and HCG in the affected and control pregnancies were compared by analysis of variance of ranks within each matched set. A probability value of
11 , 4 4 3 4 0 (199 1)
FIIIST-TRIMESTER MATERNAL SERUM ALPHAFETOPROTEIN A N D CHORIONIC GONADOTROPIN IN ANEUPLOID PREGNANCIES .4NTHONY JOHNSON*?, F. SUSAN COWCHOCK*, MARILYN DARBY$t, RONALD WAPNER*t AND LAIRD G. JACKSON* 'Division of Medical Generics and ?Division of Maternal-Fetal Medicine, Jefferson Medical College, Philadelphia, P A , U.S.A.
SUMMARY First-trimester maternal serum alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) levels were measured in samples from 29 women with cytogenetically abnormal pregnancies and 145 women with cytogeneticallynormal pregnancies matched for gestational age, race, and sample storage time. All patients had a risk of fetal aneuploidy greater than or equal to that of a mother 35 years of age. AFP was significantly lower in samples from pregnancies affected with trisomy 21 (0.67 MoM;p 0.05). Assays were completed without knowledge of the cytogenetic diagnoses. The levels of AFP and HCG in the affected and control pregnancies were compared by analysis of variance of ranks within each matched set. A probability value of
