RESEARCH ARTICLE
Functional relevance for associations between osteoporosis and genetic variants Kun Liu1, Li-Jun Tan1*, Peng Wang2, Xiang-Ding Chen1, Li-Hua Zhu2, Qin Zeng1, Yuan Hu1, Hong-Wen Deng1,3* 1 Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China, 2 Physical Examination Department, Guangxi medical university First affiliated hospital, Nanning, Guangxi, China, 3 Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States of America * [email protected] (LJT); [email protected] (HWD)
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OPEN ACCESS Citation: Liu K, Tan L-J, Wang P, Chen X-D, Zhu LH, Zeng Q, et al. (2017) Functional relevance for associations between osteoporosis and genetic variants. PLoS ONE 12(4): e0174808. https://doi. org/10.1371/journal.pone.0174808 Editor: Huiping Zhang, Yale University, UNITED STATES Received: September 20, 2016 Accepted: March 15, 2017 Published: April 3, 2017 Copyright: © 2017 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All differential expression analyses files are available from the GEO database (https://www.ncbi.nlm.nih.gov/geo/) GEO no.: GSE7158, GSE2208, GSE13850. Funding: This study was supported in part by Natural Science Foundation of China (NSFC; 81570807 to LJT, 31271344 and 31071097) and the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486). The funders had no role in study design, data collection and analysis,
Abstract Osteoporosis is characterized by increased bone loss and deterioration of bone microarchitecture, which will lead to reduced bone strength and increased risk of fragility fractures. Previous studies have identified many genetic loci associated with osteoporosis, but functional mechanisms underlying the associations have rarely been explored. In order to explore the potential molecular functional mechanisms underlying the associations for osteoporosis, we performed integrative analyses by using the publically available datasets and resources. We searched 128 identified osteoporosis associated SNPs (P
Functional relevance for associations between osteoporosis and genetic variants Kun Liu1, Li-Jun Tan1*, Peng Wang2, Xiang-Ding Chen1, Li-Hua Zhu2, Qin Zeng1, Yuan Hu1, Hong-Wen Deng1,3* 1 Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China, 2 Physical Examination Department, Guangxi medical university First affiliated hospital, Nanning, Guangxi, China, 3 Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States of America * [email protected] (LJT); [email protected] (HWD)
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OPEN ACCESS Citation: Liu K, Tan L-J, Wang P, Chen X-D, Zhu LH, Zeng Q, et al. (2017) Functional relevance for associations between osteoporosis and genetic variants. PLoS ONE 12(4): e0174808. https://doi. org/10.1371/journal.pone.0174808 Editor: Huiping Zhang, Yale University, UNITED STATES Received: September 20, 2016 Accepted: March 15, 2017 Published: April 3, 2017 Copyright: © 2017 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All differential expression analyses files are available from the GEO database (https://www.ncbi.nlm.nih.gov/geo/) GEO no.: GSE7158, GSE2208, GSE13850. Funding: This study was supported in part by Natural Science Foundation of China (NSFC; 81570807 to LJT, 31271344 and 31071097) and the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486). The funders had no role in study design, data collection and analysis,
Abstract Osteoporosis is characterized by increased bone loss and deterioration of bone microarchitecture, which will lead to reduced bone strength and increased risk of fragility fractures. Previous studies have identified many genetic loci associated with osteoporosis, but functional mechanisms underlying the associations have rarely been explored. In order to explore the potential molecular functional mechanisms underlying the associations for osteoporosis, we performed integrative analyses by using the publically available datasets and resources. We searched 128 identified osteoporosis associated SNPs (P
