Journal of Analytical Toxicology, Vol. 16, May/June 1992
Gas Chromatographic Determination of 2,5-Hexanedione in Urine as an Indicator of Exposure to n-Hexane K u s u m Vohra and V i r i n d a r S. G a i n d
Occupational Health LaboratorJ4, Ontario Ministry of Labour, 101 Resources Road, Weston, Ontario M9P 3T1, Canada
Abstract I A sensitive and specific method for determination of 2,5hexanedione in urine is described. Treatment of the urine specimen directly with n-butylamine yields n-butyl 2,5-dimethyl pyrroleo The latter is extracted into dlisopropylether and analyzed by gas chromatography (GC) with flame ionization detection (FiD), thermionic specific detection (TSD) (N mode), or mass spectrometric detection (MS). The minimum detectable quantities are 1 mg/L urine when employing FID with a coefficient of variation of
Gas Chromatographic Determination of 2,5-Hexanedione in Urine as an Indicator of Exposure to n-Hexane K u s u m Vohra and V i r i n d a r S. G a i n d
Occupational Health LaboratorJ4, Ontario Ministry of Labour, 101 Resources Road, Weston, Ontario M9P 3T1, Canada
Abstract I A sensitive and specific method for determination of 2,5hexanedione in urine is described. Treatment of the urine specimen directly with n-butylamine yields n-butyl 2,5-dimethyl pyrroleo The latter is extracted into dlisopropylether and analyzed by gas chromatography (GC) with flame ionization detection (FiD), thermionic specific detection (TSD) (N mode), or mass spectrometric detection (MS). The minimum detectable quantities are 1 mg/L urine when employing FID with a coefficient of variation of
