Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
"!
!"#"$%"&'()*+,#$)#-$./"0+)*+,#$+#$1,'."$2+0"$
5!
#$%&$!'(!)$*+",!-.//&!0$1234//5,!)6*7$4/!8(!9$*71$:"!
H!
");4?%43?$%4!@../.A&!$:B!C42$?%14:%!.=!D:%4A?$%6E4!F6./.A&,!G:6E4? W!
F;6/B6:A,!F4?+4/4&,!0I,!SJR5QTH"JQU!41$6/!+$%&$1$*+V34?+4/4&(4B;!
S!
$
"Q!
$
""!
$
"5!
$
"H!
$
"J!
$
"N!
$
"O!
$
"R!
$
"W!
$
"S!
$
5Q!
$
5"!
$
55!
$
5H!
$
5J!
$
!
"!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
5N!
34.*%)0*$
5O!
K:4!$22?.$*7!%.!;:B4?
A4:4%6*!$?*76%4*%;?4!.=!2.
=.*; 5S!
6:%4?$*%6.:
HQ!
6
N"!
^.?%&!&4$?
N5!
7;1$:
NH!
"SRN`($L6:*4!%74:,!%74?4!7$
NJ!
A4:4!?4A;/$%6.:!E4? NN!
0.&:4!5QQRU!0$??.//!5QQW`,!$:B!
?4A;/$%.?&!*7$:A4
%?$:
ON!
?42?.B;*%6E4!6
RH!
7&3?6B!
WN!
7&3?6B!1$/4
WO!
$/(!5QQW$`(!^.?!
g
7&3?6B!1$/4 SQ!
=?.1!16
SN!
612.?%$:%!6:!?42?.B;*%6E4!6
"Q"!
*7$:A4
"Q5!
Z4?4!M4!*.12$?4!4\2?4
"QJ!
?4/$%4B!6
6:!%74!
d6/$B!4%!$/(!5QQO`,!'-&T!$:B!,./0&T!E$?6$:%
"QS!
*.11.:!%7$:!4\24*%4B!3&!*7$:*4(!84!%4
"""!
_F;//$?B!4%!$/(!5Q"QU!^?$
""H!
/.A5! ""O!
B.4
""R!
4\2?4
*$:B6B$%4!A4:4
""S!
2$?%6*;/$?,!M4!%4
!
"5H!
!
"5J!
!
!
N!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
"5N!
7".'(*.$
"5O!
89*"#.+:"$!"#$%"&'()*,%;$-+:"%&"#0"$4"*
"HH!
?4A;/$%.?&!E$?6$:%
"HJ!
4\2?4
K:/&!?4$B
14$
%74!$:$/&
b74!14B6$:#?4A;/$%.?&!B6E4?A4:*4!34%M44:!
*7$:A4`!_86/*.\.:!?$:+T
*7$:A4!34%M44:!
O!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
"JS!
6:!'-$/.:4#?4/$%6E4!%.!%7.
"N5!
d4:4
"NN!
B6E6B4B!6:%.!%7?44!
"NR!
34%M44:!
7&3?6BU!5`!*.124:
$//4/4
"OH!
%74!76A74?!4\2?4
%74
B6E4?A4:*4,!%74!1$Y.?6%&!M4?4!*$%4A.?6X4B!$
*.124:
_Rl,!OJW!A4:4 "R5!
%.!'-$:B!,./0&!E$?6$:%
!
R!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
"RJ!
*.:
"RR!
,./0&,!*.124:
.=!A4:4
"WQ!
%74!
"WH!
M$
4E6B4:*4!=.?!M6B4
$
"SQ!
_F;//$?B!4%!$/(!5Q"QU!^?$
36./.A6*$/!=;:*%6.:!B4E6$%4
"SH!
36$
5Q"!
)*$+&,-'%&`(!!
5Q5!
@+.?"9/%"..+,#$+#$1;4%+-.$
5QH!
0?.
5QN!
M74:!%74!1.%74?!6
5"5!
7&3?6B!1$/4!
=.?!/.M!?4$B!*.;:%
5"N!
:;134?!.=!A4:4
*7$:A4
5"S!
3.%7!
_^6
55H!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
55J!
%74!=4?%6/4!7&3?6B!$:B!%.!%74!$;%.
55W!
$?%6=$*%!.=!B6==4?4:*4
55S!
C6
5HJ!
3.%7!
)*)$:;
5JQ!
$"#)*$+&,-'%&(!d4:4
5J"!
6:%.!)*$-0/0,,!/))-,-7+,#$:B#$-&1+43.+&&+)!_
5W!A4:4
5JH!
5JJ!
$3.E4!$:B!34/.M!%74!/4E4/!.=!3.%7! 5JR!
!
5JW!
=4?%6/4!7&3?6B!$?4!.=!6:%4?4 !
d4:4
"Q!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
5JS!
6B4:%6=64B!A4:4
5NQ!
34%M44:!%74!
5NR!
?4A;/$%6.:!.=!A4:4!4\2?4
5OQ!
.:/&!$!'-&!?4A;/$%.?&!*7$:A4!$:B!%7;
5O"!
[41$?+$3/&,!"5!.=!%74
5OJ!
LR`(!!
5ON!
!
5OO!
$?4!$
.?!$?4!76A7/&!4\2?4 *$:B6B$%4
5OS!
$:B!4\2?4
.=!.E4?/$2!34%M44:!%74!?4 5R5!
5RN!
A,2/"#.)*,%;$":,('*+,#$+.$)..,0+)*"-$
5RW!
$
5WO!
E$?6$:%
5WR!
A4:4
5SS!
M76*7!'-&1!$:B!,./0&1#E$?6$:%
HQQ!
%4
HQN!
E$?6$:%
HQO!
89/%"..+,#$0,2/)%+.,#.$4"*
B6E4?A4:*4!34%M44:!%74
$%!4\2?4
!"#$"#$%&'%(%&!_-76=4?T[6\4&!4%!$/(!5Q"J`(!876/4!-76=4?T[6\4&!4%!$/(!_5Q"J`!6:*/;B4B!1.?4!
H"J!
/6:4 H"N!
B$%$
B$%$(!84!?4T$:$/&X4B!%74!B$%$!.=!-76=4?T[6\4&!4%!$/(!_5Q"J`!=.?!%76
H"R!
M4?4!
$/(!_5Q"J`!.E4?/$2! H5Q!
$:$/& H5"!
E$?6$:%
H55!
NRl!.=!%74!A4:4
H5R!
$3.;%!'-&T!*7$:A4
H5W!
B6==4?4:%!4\2?4
HHN!
:;134?!.=!6:3?4B!/6:4 *.:*/; HHW!
?4A;/$%.?&!B6E4?A4:*4!34%M44:!%74 B+.0'..+,#!
HJQ!
84!*7$?$*%4?6X4B!?4A;/$%.?&!B6E4?A4:*4!6:!%4 HJ"!
$:B!!%$%&'%(%$%&'%(%$
HJ5!
7&3?6B
!
"J!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
HJR!
%74!6B4$!%7$%!?4A;/$%.?&!*7$:A4
HJW!
34!612.?%$:%!6:! HN"!
B6E4?A4:*4!34%M44:!!"#$"#)*$+&,-'%&!$:B!!"#$"#$%&'%(%&(!b.!16%6A$%4!%74!2.%4:%6$/!4==4*%
HN5!
6:3?44B6:A,!M4!*?.
74%4?.X&A.;
HNJ!
$22?.$*7,!M76*7!6
HNN!
A4:4!4\2?4 HNR!
$!?4
2$%%4?:
HO5!
*.??4
!
HON!
)*$+&,-'%&!M$
HOS!
%7$%!'-E$?6$:%
HRQ!
B6E4?A4:*4!6:!'-&!7$
HR"!
6:
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
HR5!
*.:%?63;%4!%.!$!/$?A4?!2?.2.?%6.:!.=!B6==4?4:%6$//&!4\2?4
7.;
HRO!
b74
3.%7!.=!M7.1!=.;:B!$!/$?A4!2?.2.?%6.:!.=!4\2?4 HW"!
?42/6*$%4
HWO!
_K
HWS!
)*$+&,-'%$:B!!"#$"#$%&'%(%&!B6E4?A4B!?.;A7/&!HNQ,QQQ!&4$?
HSQ!
$:*4
HSJ!
?4A;/$%.?&!*$%4A.?64
HSN!
"O!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
HSO!
L%$36/6X6:A! HSR!
4\2?4
JQH!
%7?.;A7!2;?6=&6:A!
*.: JQN!
J"H!
_d.:*$/E4
J"J!
IA$6: J"N!
6:!3.%7!'-&T!$:B!,./0&T,!M4!$/
_8?$&!5QQR`!$:B!
!
"R!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
J5Q!
B6?4*%6.:$/6%&(!D%!6
J5"!
$!:.:T:4A/6A63/4!2?.2.?%6.:!.=!?4A;/$%.?&!B6E4?A4:*4(!
J55!
@+.?"9/%"..+,#$+#$.*"%+("$1;4%+-.!
J5H!
D:!*?.
_'f8fLef6a`#1$/4 J5N!
*.12$?4B!%.!7&3?6B!1$/4
*.:%?63;%6:A!%.!?42?.B;*%6E4!6
$//.M!;
JHJ!
.:/&!6:! JHN!
%7$%!$?4!16 6
JHR!
$:61$/
*.:%$6:!B6==4?4:%!2?.2.?%6.:
JHS!
4\$12/4,!6:!%74!M4//T
!
"W!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
JJN!
6:*.12/4%4!6:!%74!*?. JJO!
=.;:B!6:!%74!%4 JJR!
$:61$/ JNH!
$/(!_5Q"H`! JNN!
6:!A4:4!4\2?4 $//4/4T
%&24
JO5!
%7$%!6
JOH!
!
JOJ!
1$/4!
4%!$/(!5Q""U!F7$%%$*7$?&&$!4%!$/(!5Q"J`,!274:.%&26:A!.=!6:%?.A?4
d..B!4%!$/(!5QQW3U!0$1234//!4%!$/(!5Q"HU!K+$!4%!$/(!5Q"J`,!$:B! JOR!
%74!7&3?6B!X.:4!_4(A(!b;*+4?!4%!$/(!"SS5U!C.B!4%!$/(!"SSH`,!7$E4!$//! !
9;14?.;
"S!
Downloaded from genome.cshlp.org on February 1, 2016 - Published by Cold Spring Harbor Laboratory Press
JRQ!
B6