DIABETICMedicine DOI: 10.1111/dme.13358
Research: Metabolism Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany Y. H. Ong1, W. C. A. Koh1, M. L. Ng1 , Z. Y. Tam1, S. C. Lim2, B. O. Boehm1,3,4,5, Adult-Onset Autoimmune Diabetes Mellitus Consortium (ADAMS)*
and the
1 Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, 2Clinical Research Unit, Diabetes Centre, Khoo Teck Puat Hospital, Singapore, 3Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 4Imperial College London, London, UK and 5Department of Internal Medicine 1, Ulm University Medical Centre, Ulm, Germany
Accepted 22 March 2017
Abstract Aim To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population. Methods For this cross-sectional study we recruited people with adult-onset diabetes (age of diagnosis 20–60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols. Results The prevalence of glutamic acid decarboxylase antibody positivity was 13.9% (95% CI 12.1–16.0; P
Research: Metabolism Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany Y. H. Ong1, W. C. A. Koh1, M. L. Ng1 , Z. Y. Tam1, S. C. Lim2, B. O. Boehm1,3,4,5, Adult-Onset Autoimmune Diabetes Mellitus Consortium (ADAMS)*
and the
1 Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, 2Clinical Research Unit, Diabetes Centre, Khoo Teck Puat Hospital, Singapore, 3Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 4Imperial College London, London, UK and 5Department of Internal Medicine 1, Ulm University Medical Centre, Ulm, Germany
Accepted 22 March 2017
Abstract Aim To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population. Methods For this cross-sectional study we recruited people with adult-onset diabetes (age of diagnosis 20–60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols. Results The prevalence of glutamic acid decarboxylase antibody positivity was 13.9% (95% CI 12.1–16.0; P
