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AIDS. Author manuscript; available in PMC 2016 September 24. Published in final edited form as: AIDS. 2015 September 24; 29(15): 2009–2023. doi:10.1097/QAD.0000000000000783.

Growth Reconstitution following Antiretroviral Therapy and Nutrition Supplementation: Systematic Review and MetaAnalysis Christine J. MCGRATHa, Lara DIENERb, Barbra A. RICHARDSONb,c,g, Elizabeth PEACOCKCHAMBERSh, and Grace C. JOHN-STEWARTb,d,e,f

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aDepartment

of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX

USA bDepartment

of Global Health, University of Washington, Seattle, WA USA

cDepartment

of Biostatistics, University of Washington, Seattle, WA USA

dDepartment

of Medicine, University of Washington, Seattle, WA USA

eDepartment

of Pediatrics, University of Washington, Seattle, WA USA

fDepartment

of Epidemiology, University of Washington, Seattle, WA USA

gDivision

of Vaccine and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle,

WA USA

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hPediatrics,

Boston Medical Center, Boston, MA USA

Abstract Objective—As antiretroviral treatment (ART) expands for HIV-infected children, it is important to determine its impact on growth. We quantify growth and its determinants following ART in resource-limited (RLS) and developed settings (DS). Design—Systematic review and meta-analysis.

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Methods—We searched publications reporting growth [weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) Z-scores] in HIV-infected children following ART through August 2014. Inclusion criteria: 1)