JOURNAL OF CELLULAR PHYSIOLOGY 144.429-437 (1990)
Epoxyeicosatrienoic Acids Activate Na +/H-t Exchange and Are Mitogenic in Cultured Rat Glomerular Mesangial Cells R.C. HARRIS,* T. HOMMA, H.R. JACOBSON, AND 1. CAPDEVILA Departments of Medicine ( R . C . H . , H.R.)., j.C.1, b'iocherriislry O.C.), m d Pdiatrics (T.H.), Vanderhilt lin/vcrs/ty, h'arhvi//e, Tennessee 37232 The present slucly exdrninetl responses of cultured rat glomerular mesangial cells to exogerious exposure of epoxyeicosatrienoic acids (LET'S), products of cytochrome P450 epoxygenase. One day after administration of 8,9- or I4;l S-EET, cultured rat rnesangial cells denionstratecl significant incrcases in I'HIthymidine incorporation (10 ' M I4,13-EET: '120+7')/0 otcontrol; n = 6 ; P
Epoxyeicosatrienoic Acids Activate Na +/H-t Exchange and Are Mitogenic in Cultured Rat Glomerular Mesangial Cells R.C. HARRIS,* T. HOMMA, H.R. JACOBSON, AND 1. CAPDEVILA Departments of Medicine ( R . C . H . , H.R.)., j.C.1, b'iocherriislry O.C.), m d Pdiatrics (T.H.), Vanderhilt lin/vcrs/ty, h'arhvi//e, Tennessee 37232 The present slucly exdrninetl responses of cultured rat glomerular mesangial cells to exogerious exposure of epoxyeicosatrienoic acids (LET'S), products of cytochrome P450 epoxygenase. One day after administration of 8,9- or I4;l S-EET, cultured rat rnesangial cells denionstratecl significant incrcases in I'HIthymidine incorporation (10 ' M I4,13-EET: '120+7')/0 otcontrol; n = 6 ; P
