Kaare

H &,naa,

ABSTRAC1’ the

between

phospholipid I 52 men

and

S Bjerve,

and

Arne

Nord#{248}y

We examined the cross-sectional relationships frequency of habitual fish consumption, plasma fatty acids, and serum lipids and hipoproteins in

duration

women.

g n-3

fish consumption and n-9 fatty 5n-3)

Kristian

There

was a significant

association

between

starting from 1 dish/wk and plasma n-3, n-6, acids. Plasma eicosapentaenoic acid (EPA; 20:

reflected

fish

docosahexaenoic (P < 0.05) with

consumption

acid

to a greater

(DHA;

22:6n-3).

extent

than

Triglycerides

did

decreased

fish consumption. In multivariate analysis in which anthropometric and lifestyle factors were controlled for, EPA correlated inversely with triglycerides (P < 0.05) and positively

with

high-density-lipoprotein A-I (both P < 0.001).

apolipoprotein correlate

with

triglycerides

and

(HDL)

cholesterol

and

DHA

did not

In contrast,

showed

KEY

WORDS

fatty

n-3

acids,

Fish,

cholesterol,

fatty

acid, acids,

triglycerides,

docosahexaen-

plasma

phospholipid

apohipoproteins,

lipoprotein

(DHA; and

22:6n-3)

acids

ofplasma very-low-density

content

of the

Eskimo

and

Eskimos

have

low-density

lipoproteins

Danes on a Western diet, concentrations ofhigh-density acid

(1). The

triglycerides,

1126

received

a variety

is reflected

ofdoses

American about

usual

68 studies

n-3

and Dutch

in their

is known

found

a mean

PUFA

men consume

diets

(16,

the relation

with

intake

a mean

of 8.2

g/d.

0. 15 1 and 0.14 1

17).

between

the habitual

intake

of fish and the fatty acid contents of plasma (17-19) or cells, and it is not known whether small amounts of n-3 PUFAs consumed over time as fish in an ordinary Western diet modulate lipid

or hipoprotein

cross-sectional dietary position,

metabolism.

associations

n-3 PUFA and serum

intake, lipid,

and study

design

In this

between

paper

we examine

habitual

the

fish consumption,

plasma and platelet fatty acid hipoprotein, and apolipoprotein

comcon-

centrations.

Methods Subjects

Details about the selection viously (20). During 1986women

aged

(VLDLs)

in the

ofn-3

20-56

y, and

ofparticipants 1 987, all men a random

were presented preaged 20-6 1 y, all

sample

of those

aged

12-

> =

They

were

tinue

their

antihypertensive concentrations

97 mm

Hg,

and

>

treatment and 6.00 mmol/L,

systolic

blood

who

had

serum

diastolic

blood

pressure


2.61,and itt >3.36correspondtoP