RESEARCH ARTICLE
Health-Related Quality of Life in Chinese Patients with Mild and Moderately Active Ulcerative Colitis Kai Zheng1, Shengsheng Zhang2, Chuijie Wang3, Wenxia Zhao4, Hong Shen1* 1 Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, 2 Department of Gastroenterology, Beijing Hospital of Chinese Medicine, Beijing, China, 3 Department of Gastroenterology, Affiliated Hospital of Liaoning University of Chinese Medicine, Shenyang, Liaoning, China, 4 Department of Gastroenterology, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China
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* [email protected]
Abstract Background OPEN ACCESS Citation: Zheng K, Zhang S, Wang C, Zhao W, Shen H (2015) Health-Related Quality of Life in Chinese Patients with Mild and Moderately Active Ulcerative Colitis. PLoS ONE 10(4): e0124211. doi:10.1371/ journal.pone.0124211 Academic Editor: John Green, University Hospital Llandough, UNITED KINGDOM Received: October 19, 2014 Accepted: March 10, 2015 Published: April 27, 2015 Copyright: © 2015 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This study was funded by National ministry of science and technology, supported by the National Key Technology Research and Development Program of China (grant number 2006BAI04A14), and supported by National Natural Science Foundation of China (grant number 81403343). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Ulcerative colitis (UC) impairs the health-related quality of life (HRQOL). The difference in HRQOL between patients with mild and moderately active UC is not well-defined. Few studies have been conducted to explore the factors that influence HRQOL in Chinese patients. Our study aims were to (1) compare HRQOL of mildly active UC patients with moderate patients; (2) explore the factors that influence HRQOL in Chinese patients with UC; and (3) analyze demographic and disease characteristics of UC in China.
Methods A total of 110 mild and 114 moderate patients with UC were enrolled. The demographic and disease characteristics were recorded. HRQOL was measured by the Chinese version of the inflammatory bowel disease questionnaire (IBDQ) between mild and moderate patients, male and female patients, and different disease distributions. Stepwise regression analysis was used to assess factors influencing the IBDQ score.
Results Patients with moderate UC had significantly lower IBDQ total scores compared to patients with mild UC (P=0.001). The IBDQ total score had a negative correlation with the Mayo score (r=–0.263, P
Health-Related Quality of Life in Chinese Patients with Mild and Moderately Active Ulcerative Colitis Kai Zheng1, Shengsheng Zhang2, Chuijie Wang3, Wenxia Zhao4, Hong Shen1* 1 Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, 2 Department of Gastroenterology, Beijing Hospital of Chinese Medicine, Beijing, China, 3 Department of Gastroenterology, Affiliated Hospital of Liaoning University of Chinese Medicine, Shenyang, Liaoning, China, 4 Department of Gastroenterology, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China
a11111
* [email protected]
Abstract Background OPEN ACCESS Citation: Zheng K, Zhang S, Wang C, Zhao W, Shen H (2015) Health-Related Quality of Life in Chinese Patients with Mild and Moderately Active Ulcerative Colitis. PLoS ONE 10(4): e0124211. doi:10.1371/ journal.pone.0124211 Academic Editor: John Green, University Hospital Llandough, UNITED KINGDOM Received: October 19, 2014 Accepted: March 10, 2015 Published: April 27, 2015 Copyright: © 2015 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This study was funded by National ministry of science and technology, supported by the National Key Technology Research and Development Program of China (grant number 2006BAI04A14), and supported by National Natural Science Foundation of China (grant number 81403343). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Ulcerative colitis (UC) impairs the health-related quality of life (HRQOL). The difference in HRQOL between patients with mild and moderately active UC is not well-defined. Few studies have been conducted to explore the factors that influence HRQOL in Chinese patients. Our study aims were to (1) compare HRQOL of mildly active UC patients with moderate patients; (2) explore the factors that influence HRQOL in Chinese patients with UC; and (3) analyze demographic and disease characteristics of UC in China.
Methods A total of 110 mild and 114 moderate patients with UC were enrolled. The demographic and disease characteristics were recorded. HRQOL was measured by the Chinese version of the inflammatory bowel disease questionnaire (IBDQ) between mild and moderate patients, male and female patients, and different disease distributions. Stepwise regression analysis was used to assess factors influencing the IBDQ score.
Results Patients with moderate UC had significantly lower IBDQ total scores compared to patients with mild UC (P=0.001). The IBDQ total score had a negative correlation with the Mayo score (r=–0.263, P
