International Journal of Cardiology 187 (2015) 541
Contents lists available at ScienceDirect
International Journal of Cardiology journal homepage: www.elsevier.com/locate/ijcard
Letter to the Editor
Heart donors and Takotsubo syndrome: an apology Heart donors and Takotsubo syndrome John E. Madias ⁎ Icahn School of Medicine at Mount Sinai, New York, NY, USA Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, USA
a r t i c l e
i n f o
Conflict of interest
Article history: Received 26 March 2015 Accepted 28 March 2015 Available online 31 March 2015
The authors report no relationships that could be construed as a conflict of interest.
Keywords: Takotsubo syndrome Neurogenic stress cardiomyopathy Heart donors
References
To the Editor: In a recent communication to the Journal [1] published online, I speculated that neurogenic stress cardiomyopathy (NSC) in heart donors is a form of Takotsubo syndrome (TTS). The chronology of this thought stream, on my part, which culminated to the above hypothesis, is as follows: I read 2 articles [2,3] about the epinephrine use during resuscitation of victims of cardiac arrest and worse outcomes, and this led to a speculation that such outcomes may be due to TTS [4]. In delving in the comparison of NSC and TTS, I came across the article by Mohamedali et al. [5], and through it, to the other 5 articles [6–10], I have referenced in my communication [1]. Dr. Guglin complained to the Journal that I had not quoted her articles, which are relevant to the issue of the transiently dysfunctional donor hearts as being probably due to TTS [11,12]. She is right, and I am in error for this. Indeed 2 of the reference sources [5,7] for my contribution [1], refer to Dr. Guglin's articles [11, 12], one co-authored with Dr. Novotorova [11,12]. I apologize for not quoting Dr. Guglin's articles [11,12], in my communication [1]. What I have hypothesized about donor hearts and TTS, has been proposed previously by Drs. Guglin and Novotorova [11,12].
⁎ Division of Cardiology, Elmhurst Hospital Center, 79-01 Broadway, Elmhurst, NY 11373, USA. E-mail address: [email protected].
http://dx.doi.org/10.1016/j.ijcard.2015.03.403 0167-5273/© 2015 Elsevier Ireland Ltd. All rights reserved.
[1] J.E. Madias, “Neurogenic stress cardiomyopathy in heart donors” is a form of Takotsubo syndrome, Int. J. Cardiol. 184 (Mar 4 2015) 612–613, http://dx.doi.org/ 10.1016/j.ijcard.2015.03.039 (Epub ahead of print). [2] F. Dumas, W. Bougouin, G. Geri, et al., Is epinephrine during cardiac arrest associated with worse outcomes in resuscitated patients? J. Am. Coll. Cardiol. 64 (2014) 2360–2367. [3] G.A. Ewy, The time-sensitive role of vasopressors during resuscitation of ventricular fibrillation, J. Am. Coll. Cardiol. 64 (2014) 2368–2370 (2). [4] J.E. Madias, Is the worse outcome associated with epinephrine in resuscitated patients due to Takotsubo syndrome? Int. J. Cardiol. 182C (Jan 3 2015) 223, http://dx.doi.org/10.1016/j.ijcard.2014.12.155 (Epub ahead of print). [5] B. Mohamedali, G. Bhat, A. Tatooles, A. Zelinger, Neurogenic stress cardiomyopathy in heart donors, J. Card. Fail. 20 (2014) 207–211. [6] B. Mohamedali, G. Bhat, A. Zelinger, Frequency and pattern of left ventricular dysfunction in potential heart donors: implications regarding use of dysfunctional hearts for successful transplantation, J. Am. Coll. Cardiol. 60 (2012) 235–236. [7] C. Hernandez-Caballero, R. Martin-Bermudez, J. Revuelto-Rey, M. Aguilar- Cabello, J. Villar-Gallardo, Neurogenic stunned myocardium and cardiac transplantation: a case report, Transplant. Proc. 44 (2012) 2106e10. [8] K.E. Wood, B.N. Becker, J.G. McCartney, A.M. d'Alessandro, D.B. Coursin, Care of the potential organ donor, N. Engl. J. Med. 351 (2004) 2730e9. [9] J.G. Zaroff, W.D. Babcock, S.C. Shiboski, L.L. Solinger, B.R. Rosengard, Temporal changes in left ventricular systolic function in heart donors: results of serial echocardiography, J. Heart Lung Transplant. 22 (2003) 383e8. [10] T. Kono, T. Nishina, H. Morita, Y. Hirota, K. Kawamura, A. Fujiwara, Usefulness of low-dose dobutamine stress echocardiography for evaluating reversibility of brain death induced myocardial dysfunction, Am. J. Cardiol. 84 (1999) 578e82. [11] M. Guglin, I. Novotorova, Neurogenic stunned myocardium and takotsubo cardiomyopathy are the same syndrome: a pooled analysis, Congest. Heart Fail. 17 (2011) 127–132. [12] M. Guglin, How to increase the utilization of donor hearts? Heart Fail. Rev. 20 (2015) 95–105.
Contents lists available at ScienceDirect
International Journal of Cardiology journal homepage: www.elsevier.com/locate/ijcard
Letter to the Editor
Heart donors and Takotsubo syndrome: an apology Heart donors and Takotsubo syndrome John E. Madias ⁎ Icahn School of Medicine at Mount Sinai, New York, NY, USA Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, USA
a r t i c l e
i n f o
Conflict of interest
Article history: Received 26 March 2015 Accepted 28 March 2015 Available online 31 March 2015
The authors report no relationships that could be construed as a conflict of interest.
Keywords: Takotsubo syndrome Neurogenic stress cardiomyopathy Heart donors
References
To the Editor: In a recent communication to the Journal [1] published online, I speculated that neurogenic stress cardiomyopathy (NSC) in heart donors is a form of Takotsubo syndrome (TTS). The chronology of this thought stream, on my part, which culminated to the above hypothesis, is as follows: I read 2 articles [2,3] about the epinephrine use during resuscitation of victims of cardiac arrest and worse outcomes, and this led to a speculation that such outcomes may be due to TTS [4]. In delving in the comparison of NSC and TTS, I came across the article by Mohamedali et al. [5], and through it, to the other 5 articles [6–10], I have referenced in my communication [1]. Dr. Guglin complained to the Journal that I had not quoted her articles, which are relevant to the issue of the transiently dysfunctional donor hearts as being probably due to TTS [11,12]. She is right, and I am in error for this. Indeed 2 of the reference sources [5,7] for my contribution [1], refer to Dr. Guglin's articles [11, 12], one co-authored with Dr. Novotorova [11,12]. I apologize for not quoting Dr. Guglin's articles [11,12], in my communication [1]. What I have hypothesized about donor hearts and TTS, has been proposed previously by Drs. Guglin and Novotorova [11,12].
⁎ Division of Cardiology, Elmhurst Hospital Center, 79-01 Broadway, Elmhurst, NY 11373, USA. E-mail address: [email protected].
http://dx.doi.org/10.1016/j.ijcard.2015.03.403 0167-5273/© 2015 Elsevier Ireland Ltd. All rights reserved.
[1] J.E. Madias, “Neurogenic stress cardiomyopathy in heart donors” is a form of Takotsubo syndrome, Int. J. Cardiol. 184 (Mar 4 2015) 612–613, http://dx.doi.org/ 10.1016/j.ijcard.2015.03.039 (Epub ahead of print). [2] F. Dumas, W. Bougouin, G. Geri, et al., Is epinephrine during cardiac arrest associated with worse outcomes in resuscitated patients? J. Am. Coll. Cardiol. 64 (2014) 2360–2367. [3] G.A. Ewy, The time-sensitive role of vasopressors during resuscitation of ventricular fibrillation, J. Am. Coll. Cardiol. 64 (2014) 2368–2370 (2). [4] J.E. Madias, Is the worse outcome associated with epinephrine in resuscitated patients due to Takotsubo syndrome? Int. J. Cardiol. 182C (Jan 3 2015) 223, http://dx.doi.org/10.1016/j.ijcard.2014.12.155 (Epub ahead of print). [5] B. Mohamedali, G. Bhat, A. Tatooles, A. Zelinger, Neurogenic stress cardiomyopathy in heart donors, J. Card. Fail. 20 (2014) 207–211. [6] B. Mohamedali, G. Bhat, A. Zelinger, Frequency and pattern of left ventricular dysfunction in potential heart donors: implications regarding use of dysfunctional hearts for successful transplantation, J. Am. Coll. Cardiol. 60 (2012) 235–236. [7] C. Hernandez-Caballero, R. Martin-Bermudez, J. Revuelto-Rey, M. Aguilar- Cabello, J. Villar-Gallardo, Neurogenic stunned myocardium and cardiac transplantation: a case report, Transplant. Proc. 44 (2012) 2106e10. [8] K.E. Wood, B.N. Becker, J.G. McCartney, A.M. d'Alessandro, D.B. Coursin, Care of the potential organ donor, N. Engl. J. Med. 351 (2004) 2730e9. [9] J.G. Zaroff, W.D. Babcock, S.C. Shiboski, L.L. Solinger, B.R. Rosengard, Temporal changes in left ventricular systolic function in heart donors: results of serial echocardiography, J. Heart Lung Transplant. 22 (2003) 383e8. [10] T. Kono, T. Nishina, H. Morita, Y. Hirota, K. Kawamura, A. Fujiwara, Usefulness of low-dose dobutamine stress echocardiography for evaluating reversibility of brain death induced myocardial dysfunction, Am. J. Cardiol. 84 (1999) 578e82. [11] M. Guglin, I. Novotorova, Neurogenic stunned myocardium and takotsubo cardiomyopathy are the same syndrome: a pooled analysis, Congest. Heart Fail. 17 (2011) 127–132. [12] M. Guglin, How to increase the utilization of donor hearts? Heart Fail. Rev. 20 (2015) 95–105.
