Oncology Heavy Cigarette Smoking and Aggressive Bladder Cancer at Initial Presentation Eugene J. Pietzak, Phillip Mucksavage, Thomas J. Guzzo, and S. Bruce Malkowicz OBJECTIVE METHODS

RESULTS

CONCLUSION

To identify the impact of smoking intensity on tumor characteristics at the time of initial bladder cancer diagnosis. We retrospectively reviewed our institution’s prospective database of patients diagnosed with bladder cancer from 1987 to 2009. Only patients with urothelial cell carcinoma and recorded tobacco history were included. Patients were stratified by tobacco history into nonsmokers, light smokers (
30 pack-years), and heavy smokers (>30 pack-years). An additional analysis was performed looking at patients meeting National Lung Cancer Screening Trial (NLCST) criteria (55- to 74-year-old patients with 30 pack-years smoking history and 30 PackYears)

197 (26.6%) 66 (57.6-74.2)

251 (33.9%) 64 (55.3-72)

292 (39.5%) 66.8 (59.9-72.6)

128 (65%) 69 (35%) 26.6 (23.5-29.8)

181 (72%) 70 (28%) 27.3 (24.4-29.8)

248 (85%) 43 (15%) 26.6 (24.4-30.4)

159 (90%) 13 (7%) 5 (3%) 0 0

209 (91%) 18 (8%) 3 (1%) 0.99 19.4 176 (70%) 20.3

248 (95%) 10 (4%) 4 (1%) 1.7 36.1 145 (50%) 13.9

0

0.2