754
6. Mak KKW, Gude NM, Walters WAW, Boura ALA. Effects of vasoactive autacoids on the human umbilical-fetal placental vasculature. Br J Obstet Gynaecol 1984; 91: 99-106. 7. Fitzgerald DJ, FitzGerald GA. Eicosanoids in the pathogenesis of preeclampsia. In: Laragh JH, Brenner BM, eds. Hypertension: physiology, diagnosis, and management. New York: Raven Press, 1989: 1789-807. 8. Redman CWG, Bonnar J, Beilin L. Early platelet consumption in pre-eclampsia. Br Med J 1978; i: 467-70. 9. Kaar K, Jouppila P, Kuikka J, Loutola H, Toivanen J, Rekonen A. Intevillous blood flow in normal and complicated late pregnancy measured by means of an intravenous 133XE method. Acta Obstet Gynecol Scand 1980; 59: 7-10. 10. Fitzgerald DJ, Mayo G, Catella F, Entman SS, FitzGerald GA. Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets. Am J Obstet Gynecol 1987; 157: 325-30. 11. Catella F, FitzGerald GA. Paired analysis of urinary thromboxane B2 metabolites in urine. Thromb Res 1987; 47: 647-56. 12. Catella F, Healy D, Lawson J, FitzGerald GA. 11-dehydrothromboxane B2: an index of thromboxane formation in the human circulation. Proc Natl Acad Sci USA 1986; 83: 5861-65. 13. Liggins GC, Campos GA, Roberts CM, Skinner CJ. Production rates of prostaglandin F2&agr;, 6-keto-PGF1&agr;and thromboxane B2 by perfused human endometrium. Prostaglandins 1980; 19: 461-77. 14. Socol ML, Weiner CP, Louis G, Rehnberg K, Rossi EC. Platelet activation in preeclampsia. Am J Obstet Gynecol 1985; 151: 494-97. 15. Jespersen J. Disseminated intravascular coagulation in toxemia of pregnancy. Correction of the decreased platelet counts and raised levels of serum and fibrin (ogen) degradation products by aspirin. Thromb Res 1980; 17: 743-46. 16. Granstrom E, Diczfalusy U, Hamberg M, Malmsten C, Samuelsson B. Thromboxane A2: biosynthesis and effect on platelets. Adv Prostagland Leuk Res 1982; 10: 15-57.
Fitzgerald DJ, Entman SS, Mulloy K, FitzGerald GA. Decreased prostacyclin biosynthesis preceding the clinical manifestations of pregnancy-induced hypertension. Circulation 1987; 75: 956-63. 18. Lam JYT, Cheseboro JH, Steele PH, Fuster V. Is vasospasm related to platelet deposition? In vivo relationship ina pig model or arterial injury. 17.
19.
20. 21.
22.
23.
24.
25.
26.
27.
Circulation 1987; 75: 342. Catella F, Roy L, FitzGerald GA. Marked platelet activation in vivo after streptokinase in patients with acute myocardial infarction. Circulation 1988; 77: 142-50. McKay DG. Chronic intravascular coagulation in normal pregnancy and preeclampsia. Contr Nephrol 1981; 25: 108-19. Mento P, Hedberg A, Liu E, Hollander A, Wilkes B. Evidence for TxA2 receptor sites linked to modulation of fetoplacental vascular resistance in the human placenta. Clin Res 1988; 36: 387A. Keith JC. Beneficial effect of a U63557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension. Am J Obstet Gynecol 1987; 157: 199-203. Everett SB, Worley RJ, MacDonald PC, Gant NF. Effect of prostaglandin synthase inhibitors on the pressor response to angiotensin II in human pregnancy. J Clin Endocrinol Metab 1978; 46: 1007-10. Broughton-Pipkin F, Morrison R, O’Brien PMS. Effects of prostacyclin on the pressor response to angiotensin II in human pregnancy (abstr). Eur J Clin Invest 1984; 14: 3. Stuart MJ, Gross SJ, Elrad H, Graeber JE. Effects of acetylsalicylic acid ingestion on maternal and neonatal hemostasis. N Engl J Med 1982; 307: 909-12. Pedersen AK, FitzGerald GA. Dose related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med 1984; 311: 1206-11. FitzGerald GA, Lupinetti M, Charman SA, Charman WN. Presystemic acetylation of platelet cyclooxygenase: selective inhibition by controlled release-low dose aspirin. JACC (in press).
Fitzgerald DJ,
Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result?
An enzyme immunoassay (Ortho-HCV ELISA) for antibodies against the hepatitis C virus (HCV) was used to test 143 serum samples from 53 patients with autoimmune chronic active hepatitis (AI-CAH). Optical density (OD) values in the assay correlated closely with serum globulin (r=0·8846, and IgG (r=0·6281, p
6. Mak KKW, Gude NM, Walters WAW, Boura ALA. Effects of vasoactive autacoids on the human umbilical-fetal placental vasculature. Br J Obstet Gynaecol 1984; 91: 99-106. 7. Fitzgerald DJ, FitzGerald GA. Eicosanoids in the pathogenesis of preeclampsia. In: Laragh JH, Brenner BM, eds. Hypertension: physiology, diagnosis, and management. New York: Raven Press, 1989: 1789-807. 8. Redman CWG, Bonnar J, Beilin L. Early platelet consumption in pre-eclampsia. Br Med J 1978; i: 467-70. 9. Kaar K, Jouppila P, Kuikka J, Loutola H, Toivanen J, Rekonen A. Intevillous blood flow in normal and complicated late pregnancy measured by means of an intravenous 133XE method. Acta Obstet Gynecol Scand 1980; 59: 7-10. 10. Fitzgerald DJ, Mayo G, Catella F, Entman SS, FitzGerald GA. Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets. Am J Obstet Gynecol 1987; 157: 325-30. 11. Catella F, FitzGerald GA. Paired analysis of urinary thromboxane B2 metabolites in urine. Thromb Res 1987; 47: 647-56. 12. Catella F, Healy D, Lawson J, FitzGerald GA. 11-dehydrothromboxane B2: an index of thromboxane formation in the human circulation. Proc Natl Acad Sci USA 1986; 83: 5861-65. 13. Liggins GC, Campos GA, Roberts CM, Skinner CJ. Production rates of prostaglandin F2&agr;, 6-keto-PGF1&agr;and thromboxane B2 by perfused human endometrium. Prostaglandins 1980; 19: 461-77. 14. Socol ML, Weiner CP, Louis G, Rehnberg K, Rossi EC. Platelet activation in preeclampsia. Am J Obstet Gynecol 1985; 151: 494-97. 15. Jespersen J. Disseminated intravascular coagulation in toxemia of pregnancy. Correction of the decreased platelet counts and raised levels of serum and fibrin (ogen) degradation products by aspirin. Thromb Res 1980; 17: 743-46. 16. Granstrom E, Diczfalusy U, Hamberg M, Malmsten C, Samuelsson B. Thromboxane A2: biosynthesis and effect on platelets. Adv Prostagland Leuk Res 1982; 10: 15-57.
Fitzgerald DJ, Entman SS, Mulloy K, FitzGerald GA. Decreased prostacyclin biosynthesis preceding the clinical manifestations of pregnancy-induced hypertension. Circulation 1987; 75: 956-63. 18. Lam JYT, Cheseboro JH, Steele PH, Fuster V. Is vasospasm related to platelet deposition? In vivo relationship ina pig model or arterial injury. 17.
19.
20. 21.
22.
23.
24.
25.
26.
27.
Circulation 1987; 75: 342. Catella F, Roy L, FitzGerald GA. Marked platelet activation in vivo after streptokinase in patients with acute myocardial infarction. Circulation 1988; 77: 142-50. McKay DG. Chronic intravascular coagulation in normal pregnancy and preeclampsia. Contr Nephrol 1981; 25: 108-19. Mento P, Hedberg A, Liu E, Hollander A, Wilkes B. Evidence for TxA2 receptor sites linked to modulation of fetoplacental vascular resistance in the human placenta. Clin Res 1988; 36: 387A. Keith JC. Beneficial effect of a U63557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension. Am J Obstet Gynecol 1987; 157: 199-203. Everett SB, Worley RJ, MacDonald PC, Gant NF. Effect of prostaglandin synthase inhibitors on the pressor response to angiotensin II in human pregnancy. J Clin Endocrinol Metab 1978; 46: 1007-10. Broughton-Pipkin F, Morrison R, O’Brien PMS. Effects of prostacyclin on the pressor response to angiotensin II in human pregnancy (abstr). Eur J Clin Invest 1984; 14: 3. Stuart MJ, Gross SJ, Elrad H, Graeber JE. Effects of acetylsalicylic acid ingestion on maternal and neonatal hemostasis. N Engl J Med 1982; 307: 909-12. Pedersen AK, FitzGerald GA. Dose related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med 1984; 311: 1206-11. FitzGerald GA, Lupinetti M, Charman SA, Charman WN. Presystemic acetylation of platelet cyclooxygenase: selective inhibition by controlled release-low dose aspirin. JACC (in press).
Fitzgerald DJ,
Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result?
An enzyme immunoassay (Ortho-HCV ELISA) for antibodies against the hepatitis C virus (HCV) was used to test 143 serum samples from 53 patients with autoimmune chronic active hepatitis (AI-CAH). Optical density (OD) values in the assay correlated closely with serum globulin (r=0·8846, and IgG (r=0·6281, p
